Arthropodicidal pyrazolines, pyrazolidines and hydrazines

ABSTRACT

Compounds of Formula I ##STR1## wherein Q, W, R 1  and m are as defined in the text; these compounds being useful in controlling agronomic and nonagronomic arthropods.

CROSS-REFERENCE TO RELATED APPLICATIONS

This is a continuation-in-part of U.S. applications bearing Ser. Nos.07/472,901 filed on Jan. 31, 1990 and continuation-in-part 07/473,795filed on Feb. 2, 1990, both now abandoned.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention concerns arthropodicidal pyrazolines, pyrazolidines andhydrazines and their use to control arthropods.

2. State of the Art

These publications disclose insecticidal pyrazolines: WO 88/07,994, EPA330,678, U.S. Pat. No. 4,070,365, and EPA 153,127. They are, however,not especially relevant to the class of pyrazolines described herein.These publications disclose pyrazolidines: J. Org. Chem., 1987, 52, 2277and Chem. Soc. Japan, 1982, 55, 2450.

SUMMARY OF THE INVENTION

The invention pertains to compounds of Formula I including all geometricand stereoisomers, agriculturally suitable salts thereof, agriculturalcompositions containing them and their use for the control of arthropodsin both agronomic and nonagronomic environments. The compounds are:##STR2## wherein:

Q is attached to the carbon terminus of W and is selected from the group##STR3##

W is selected from the group ##STR4## wherein: V is selected from thegroup O, S, NR¹¹ and CH₂ optionally substituted with 1-2 CH₃ ;

A is selected from the group O, S, NR¹¹, CH₂, CH₂ optionally substitutedwith a group selected from C₁ -C₄ alkyl and CH₂ optionally substitutedwith phenyl which is optionally substituted with R¹² ;

X is selected from the group O and S;

X¹ is selected from the group Cl, Br, OR⁶, SR⁶, and NR⁶ R⁷ ;

X² is selected from the group R⁶, OH, OR⁶, CN, SO₂ R⁶, OC(O)NR⁷ R⁸,OC(O)OCH₃, NR⁷ R⁸, phenyl optionally substituted with R⁹ and SO₂ Phoptionally substituted with R⁹ ;

Y is selected from the group H, C₁ -C₆ alkyl, benzyl, C₂ -C₆alkoxyalkyl, CHO, C₂ -C₆ alkylcarbonyl, C₂ -C₆ alkoxycarbonyl, C₂ -C₆haloalkylcarbonyl, C₁ -C₆ alkylthio, C₁ -C₆ haloalkylthio, phenylthio,R¹⁷ OC(O)N(R)¹⁸ S and SN(R¹⁹)R²⁰ ;

Y¹ is selected from the group H, C₁ -C₃ alkyl, C₂ -C₃ alkylcarbonyl andC₂ -C₃ alkoxycarbonyl;

R is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄alkoxycarbonyl, C₂ -C₄ haloalkylcarbonyl, C₂ -C₄ alkoxycarbonyl, C₂ -C₄haloalkoxycarbonyl, C₂ -C₅ alkylcarbamoyl, C₃ -C₆ cycloalkyl, C₃ -C₆halocycloalkyl, C₄ -C₇ alkylcycloalkyl, C₄ -C₇ haloalkylcycloalkyl, C₁-C₄ alkylsulfonyl, C₁ -C₄ haloalkylsulfonyl and SO₂ Ph;

R¹, R², R⁹, R¹⁰, R¹², R¹⁴, R¹⁵ and R¹⁶ are each independently selectedfrom the group H, halogen, CN, C₁ -C₃ haloalkyl, C₁ -C₃ haloalkoxy andOS(O)₂ C₁ -C₃ haloalkyl;

R³ is selected from the group H, C₁ -C₆ alkyl, C₂ -C₆ alkenyl, CO₂ R¹³and phenyl optionally substituted by (R¹⁴)_(p) ;

R⁴ is selected from the group H, C₁ -C₆ alkyl, C₂ -C₆ alkenyl and phenyloptionally substituted with (R¹⁶)_(s) ;

R⁵ is selected from the group H and C₁ -C₄ alkyl;

R⁶ is selected from the group C₁ -C₃ alkyl, benzyl optionallysubstituted with R⁹, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl, C₁ -C₃ haloalkyl,C₂ -C₄ haloalkenyl, C₂ -C₃ alkoxycarbonyl, C₃ -C₆ cycloalkyl and C₂ -C₃alkylcarbonyl; or R⁶ is C₁ -C₃ alkyl substituted with a member selectedfrom the group OCH₃, OCH₂ CH₃, NO₂, CN, CO₂ CH₃, CO₂ CH₂ CH₃, SCH₃ andSCH₂ CH₃ ;

R⁷ is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄alkoxycarbonyl, phenyl optionally substituted with R¹⁰ and pyridyloptionally substituted with R¹⁰ ;

R⁶ and R⁷ can be taken together as CH₂ CH₂ CH₂ CH₂, CH₂ CH₂ CH₂ CH₂ CH₂,or CH₂ CH₂ OCH₂ CH₂ when X¹ is NR⁶ R⁷ ;

R⁸ is selected from the group H and C₁ -C₄ alkyl;

R⁷ and R⁸ can be taken together as CH₂ CH₂ CH₂ CH₂, CH₂ CH₂ CH₂ CH₂ CH₂,or CH₂ CH₂ OCH₂ CH₂ ;

R¹¹ is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₁ -C₃alkylsulfonyl, C₂ -C₅ alkylcarbamoyl, C₂ -C₃ alkylcarbonyl, C₂ -C₃haloalkylcarbonyl, C₂ -C₄ alkenyl, C₂ -C₄ haloalkenyl, C₂ -C₄alkoxycarbonyl, phenyl optionally substituted with R¹⁵ and benzyloptionally substituted with R¹⁵ ;

R¹³ is selected from the group H and C₁ -C₃ alkyl;

R¹⁷ is selected from C₁ -C₆ alkyl;

R¹⁸ is selected from C₁ -C₆ alkyl;

R¹⁹ and R²⁰ are independently C₁ -C₄ alkyl; or

R¹⁹ and R²⁰ can be taken together as CH₂ CH₂ CH₂ CH₂ CH₂ or CH₂ CH₂ OCH₂CH₂ ;

m is 1 or 2;

n is 1 or 2;

p is 1 or 2; and

s is 1 or 2;

i) wherein when Q is Q-4 and W is W-3 then R⁵ is H and R³ is selectedfrom the group H, C₁ -C₆ alkyl and phenyl substituted by (R¹⁴)_(p) ;

ii) wherein when Q is Q-1 to Q-5, then W is W-2 or W-3.

In the above definitions, the term "alkyl", used either alone or incompounds words such as "alkylthio" or "haloalkyl", denotes straightchain or branched alkyl such as methyl, ethyl, n-propyl, isopropyl orthe different butyl, pentyl, hexyl isomers. Alkoxy denotes methoxy,ethoxy, n-propyloxy, isopropyloxy and the different butoxy, pentoxy orhexoxy isomers. Alkenyl denotes straight chain or branched alkenes suchas vinyl, 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl,pentenyl and hexenyl isomers. Alkynyl denotes straight chain or branchedalkynes such as ethynyl, 1-propynyl, 3-propynyl and the differentbutynyl, pentynyl and hexynyl isomers. Alkylthio denotes methylthio,ethylthio and the different propylthio, butylthio, pentylthio andhexylthio isomers. Alkylsulfinyl, alkylsulfonyl, alkylamino, and thelike, are defined analogously to the above examples. Cycloalkyl denotescyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The term "halogen", either alone or in compound words such as"haloalkyl", denotes fluorine, chlorine, bromine or iodine. Further,when used in compound words such as "haloalkyl" said alkyl can bepartially or fully substituted with halogen atoms, which can be the sameor different. Examples of haloalkyl include CH₂ CH₂ F, CF₂ CF₂ H and CH₂CHFCl. The terms "halocyclo- alkyl", "haloalkenyl" and "haloalkynyl" aredefined analogously to the term "haloalkyl".

The total number of carbon atoms in a substituent group is indicated bythe "C_(i) -C_(j) " prefix where i and j are numbers from 1 to 8. Forexample, C₁ -C₃ alkylsulfonyl designates methylsulfonyl throughpropylsulfonyl; C₂ alkoxyalkoxy designates OCH₂ OCH₃ ; C₄ alkoxyalkoxydesignates the various isomers of an alkoxy group substituted with asecond alkoxy group containing a total of 4 carbon atoms, examplesincluding OCH₂ OCH₂ CH₂ CH₃ and OCH₂ CH₂ OCH₂ CH₃ ; C₂ cyanoalkyldesignates CH₂ CH and C₃ cyanoalkyl designates CH₂ CH₂ CN and CH(CN)CH₃; C₂ alkylcarbonyl designates C(O)CH₃ and C₄ alkylcarbonyl includesC(O)CH₂ CH₂ CH₃ and C(O)CH(CH₃)₂ ; and as a final example, C₃alkoxycarbonylalkyl designates CH₂ CO₂ CH₃ and C₄ alkoxycarbonylalkylincludes CH₂ CH₂ CO₂ CH₃, CH₂ CO₂ CH₂ CH₃ and CH(CH₃)CO₂ CH₃.

Preferred Compounds A are those compounds of Formula I wherein:

X is O;

X¹ is selected from the group Cl, SR⁶, N(CH₃)₂ and OR⁶ ;

X² is selected from the group CN, OR⁶, OH and N(CH₃)₂ ;

V is selected from the group CH₂ and O;

A is selected from the group CH₂ and O;

R is H;

R¹, R², R¹⁴ and R¹⁶ are each independently selected from the group H, F,Cl, Br, CF₃, OCF₃, OCF₂ H, OCH₂ CF₃ and OSO₂ CF₃ ;

R³ is selected from the group CO₂ CH₃, CH(CH₃)₂, CH₃ and phenyloptionally substituted with R¹⁴ ;

R⁴ is selected from the group CH₃, CH(CH₃)₂ and phenyl optionallysubstituted with R¹⁶ ;

R⁵ is selected from the group H and CH₃ ;

R⁶ is C₁ -C₂ alkyl;

R¹¹ is selected from the group H, CH₃, SO₂ CH₃, C(O)CH₃, C(O)NHCH₃ andCO₂ CH₃ ;

Y is selected from the group H, C(O)CH₃, CH₃ and CO₂ CH₃ ; and

m and n are 1.

Preferred Compounds B are those compounds of Preferred A wherein Q isQ-1 and W is W-2.

Preferred Compounds C are those compounds of Preferred A wherein Q isQ-3 and W is W-2.

Preferred Compounds D are those compounds of Preferred A wherein Q isQ-1 and W is W-3.

Preferred Compounds E are those compounds of Preferred A wherein Q isQ-3 and W is W-3.

Preferred Compounds F are those compounds of Preferred A wherein Q isQ-6 and W is W-1.

Preferred Compounds G are those compounds of Preferred A wherein Q isQ-8 and W is W-1.

DETAILS OF THE INVENTION

Compounds of Formula I can be prepared as described in Schemes 1 through24 and the previously defined variables will remain as defined unlessotherwise noted.

Compounds of the Formula I (Q-1, W-2 or W-3) can be prepared by thereaction of imidoylhalides of the Formula I (Q-1, W-2) with sulfur,oxygen and nitrogen nucleophiles of the Formula III as illustrated inScheme 1. Typical reactions involve the combination of equimolar amountsof I (Q-1, W-2) and III in the presence of a base such as an alkalimetal, tertiary amine, metal hydride and the like in conventionalorganic solvents, including ether, tetrahydrofuran 1,2-dimethoxyethane,methylene chloride, chloroform, N,N-dimethylformamide anddimethylsulfoxide. The reaction can be conducted at temperatures rangingfrom -20° C. to 100° C. with temperatures in the range of -10° C. to 30°C. generally being preferred. One skilled in the art should recognizethat reactions of this general type can be extended to othernucleophilic reagents. ##STR5##

Compounds of the Formula I (Q-1, W-2) can be prepared by the reaction ofFormula IV compound with an appropriate halogenating agent such asphosphorous trichloride, phosphorous pentachloride, phosphoroustribromide, phosphorous pentabromide, thionyl chloride, sulfurylchloride, triphenyl phosphine and carbon tetrachloride (Wolkoff, Can. J.Chem., 1975, 53, 1333) and the like (see Fieser and Fieser, Reagents forOrganic Synthesis, Vol. I, 1967) as illustrated in Scheme 2. Typicalreactions involve the combination of Formula IV compounds with an excessof the halogenating agent ranging from 1.1 to 10 equivalents, with 2 to4 equivalents being preferred. The reaction can be conducted in theabsence of a solvent or in the presence of a conventional organicsolvent such as benzene, toluene, xylene, chloroform, methylenechloride, hexane and the like. The reaction temperature can range from-10° C. to 200° C. with 35° C. to 100° C. being preferred. The reactionis generally complete after 24 hours. ##STR6##

The preparation of Formula IV compounds is known. Compounds of Formula I(Q-1, W-2), when X¹ is equal to R⁶ -S, can be prepared by the reactionof compounds of Formula V with an electrophile of Formula VI in thepresence of a suitable base, as illustrated in Scheme 3. Typicalreactions involve the combination of equimolar amounts of Formula Vcompounds and the appropriate electrophile of Formula VI. A base such asan alkali metal, tertiary amine or metal hydride can be used. ##STR7##

Preparation of compounds of Formula V is known. Compounds of the FormulaI (Q-2, W-2 or W-3) can be prepared from Formula I (Q-2, W-2)derivatives in an analogous fashion as that described for thepreparation of Formula I (Q-1, W-2) compounds. Scheme 4 illustrates thismethod. ##STR8##

Formula I (Q-2, W-2) compounds can be prepared from Formula VIIcompounds in an analogous fashion as that described for Formula I (Q-1,W-2) compounds. Scheme 5 illustrates this method. ##STR9##

Compounds of Formula VII can be prepared by the reaction of the acidchloride VIII with a substituted aniline of Formula IX in equimolarproportions in the presence of an excess of acid scavenger, such astertiary alkylamines or pyridines, but not limited to these, in anaprotic organic solvent such as ether, tetrahydrofuran, chloroform,methylene chloride, benzene and/or toluene. Scheme 6 illustrates thistransformation. ##STR10##

Compounds of the Formula VIII can be prepared from compounds of theFormula X through conventional methodology generally used for theconversion of esters to their corresponding acid chlorides asillustrated in Scheme 7. ##STR11##

Compounds of Formula X can be obtained by the intramolecular dipolarcycloaddition reaction of nitrile-imines, generated from substitutedphenylhydrazones of Formula XI (Scheme 8). The presence of an acidacceptor (generally an amine base, for example, triethylamine) isnecessary for the formation of the nitrile-imine. Suitable solventsinclude, but are not restricted to benzene, toluene, 1,2-dichloroethane,chloroform, and tetrahydrofuran. The reaction can be carried out attemperatures ranging from 20° to 120° C with the relative reactivity ofthe alkene moiety governing the required temperature. ##STR12##

The required hydrazones of Formula XI can be synthesized by theJapp-Klingemann reaction (Scheme 9). The coupling of diazonium saltswith active methylene compounds is known. The more specific coupling ofchloroacetoacetic acid derivatives of Formula XIII with diazotizedanilines of Formula XII containing alkenyl substitutents is described inJ. Org. Chem., 43, 1664 (1978) and J. Org. Chem., 46, 1402 (1981). Asimilar process for this type of aniline is described in J. Org. Chem.,42, 1389(1977), and J. Chem. Soc., Perkin I, 2245 (1981). ##STR13##

Compounds of the Formula XII can be prepared by conventional methodsknown to one skilled in the art.

The Formula I (Q-3, W-3) compounds can be prepared from Formula I (Q-3,W-2) derivatives in an analogous fashion as that described for thepreparation of Formula I (Q-1, W-3) compounds. Scheme 10 illustratesthis method. ##STR14##

The compounds of the Formula I (Q-3, W-2) can be prepared from FormulaXIV derivatives in an analogous fashion as that described for Formula I(Q-1, W-2) compounds. Scheme 11 illustrates this method. ##STR15##

The compounds of Formula XIV can be prepared by the reaction ofhydrazones of Formula XV with an aryl isocyanate of Formula XVI (Scheme12). Typical reactions involve combination of equimolar amounts of XVand XVI in a suitable solvent at temperatures generally in the range of-10° C. to 100° C. Although the reaction can be run neat, a solvent isgenerally preferred. Suitable solvents typically have sufficientpolarity to effect solution of the Formula XV hydrazones including, butnot limited to, ethers such as diethyl ether, tetrahydrofuran anddioxane; halogenated hydrocarbons such as methylene chloride, chloroformand carbon tetrachloride; aromatic hydrocarbons such as benzene, tolueneand xylene; esters such as ethyl acetate and polar aprotic solvents suchas dimethylformamide and dimethylacetamide. ##STR16##

The hydrazones of Formula XV can be obtained by processes known in theart involving condensation of a ketone of Formula XVII with hydrazine(Scheme 13). This reaction is typically conducted with equimolar amountsof XVII and hydrazine although greater than stoichiometric amounts ofhydrazine can be used. Suitable solvents include the alcohols such asmethanol, ethanol, propanol, butanol and the like at temperatures in therange of 0° to 150° C., with the reflux temperature of the solventgenerally being a convenient reaction temperature. Acid catalysis canalso be useful, particularly for some of the more sterically hinderedFormula XVII compounds. Typical acid catalysts include sulfuric,hydrochloric and p-toluene sulfonic acid. ##STR17##

The starting ketones of Formula XVII are known in the art or can beobtained by methods analogous to known procedures. Those skilled in theart will recognize the Formula XVII compounds to include indanones,tetralones, chromanones, thiochromanones, benzofuran-3-ones,thiobenzofuran-3-ones, isochromanones and others.

The compounds of Formula I (Q-4, W-2 or W-3) can be prepared fromFormula I (Q-4, W-2) derivatives in an analogous fashion as thatdescribed for the preparation of Formula I (Q-1, W-2 or W-3) compounds.Scheme 14 illustrates this method. ##STR18##

Formula I (Q-4, W-2 or W-3) compounds can be prepared from Formula XVIIIderivatives in an analogous fashion as that described for Formula I(Q-1, W-2) compounds. Scheme 15 illustrates this method. ##STR19##

The preparation of compounds of Formula XVIII is known. The Formula I(Q-5, W-2 or W-3) compounds can be prepared from Formula I (Q-5, W-2)derivatives in an analogous fashion as that described for thepreparation of Formula I (Q-1, W-2 or W-3) compounds. Scheme 16illustrates this method. ##STR20##

Formula I (Q-5, W-2) compounds can be prepared from Formula XIXderivatives in an analogous fashion as that described for Formula I(Q-1, W-2) compounds. Scheme 17 illustrates this method. ##STR21##

Compounds of Formula I (Q-6, W-1) wherein R is equal to H can beprepared by the reaction of aryl isocyanates of Formula XVI withsubstituted pyrazolidines of Formula XXI as illustrated in Scheme 18.Typical reactions involve the combination of equimolar amounts of XVIand XXI in conventional organic solvents including ethyl acetate, ether,tetrahydrofuran, methylene chloride, chloroform, benzene and toluene butnot restricted to these. The reaction can be conducted at temperaturesranging from -20° C. to 100° C. with temperatures in the range of -10°C. to 30° C. generally preferred. ##STR22##

Compounds of Formula XXI can be prepared by the reaction of hydrazinedihydrochloride or hydrazine sulfate with compounds of Formula XXII asillustrated in Scheme 19. Modification of the procedure described inBull. Chem. Soc. Jap., 1982, 55, 2450, and J. Org. Chem., 1987, 52,2277, can be applied to the synthesis of compounds of the Formula XXI.Typical reactions involved the addition of an excess of hydrazinedihydrochloride or hydrazine sulfate, ranging from 1.1 to 20 equivalentswith 5 to 15 equivalents being preferred, to one equivalent of acompound of Formula XXII in an alcohol/water solvent mixture rangingfrom 1 to 99% alcohol with 90% to 95% alcohol being preferred. Typicalalcoholic solvents include methanol, ethanol, n-propanol, n-butanol,tert-butanol and the like. The reaction can be conducted at temperaturesranging from -20° C. to 140° C. with temperatures in the range of 20° C.to 80° C. being preferred. The reaction is usually complete within 24hours. ##STR23## Substituted benzaldehydes of Formula XXII can beprepared utilizing known methods or obvious modifications thereof by oneskilled in the art.

Compounds of formula I (Q-6, W-1) where R is not equal to H can beprepared by the reaction of Formula I (Q-6, W-1) compounds where R isequal to H with a variety of electrophiles. For example, theseelectrophiles include, but are not limited to, alkyl halides, alkyl andaryl isocyanates, acyl halides, sulfonyl halides and alkylchlorocarbonates. Reactions to prepare Formula I (Q-6, W-1) compoundswhere R is not equal to H can be conducted through standard proceduresknown to those skilled in the art. For example, the reaction of FormulaI (Q-6, W-1) compounds where R is equal to H with methyl isocyanate(Scheme 20) can be conducted by reaction of equal molar amounts of thereactants in an inert solvent such as, but not limited to, ether,tetrahydrofuran, dimethoxyethane, ethyl acetate, methylene chloride andchloroform, in the presence of an acid scavenger such as tertiaryalkylamines, substituted pyridines, alkali metals, and the like.##STR24##

Compounds of Formula I (Q-7, W-1) can be prepared by the reaction oftri- and tetravalent metal species such as titanium, silicon, tin andthe like in combination with a reducing agent such as sodium, lithium,or zinc borohydride, lithium aluminum hydride and the like withcompounds of Formula VII as illustrated in Scheme 21. Literatureprecedent for analogous reactions can be found in J. Org. Chem., 1987,54, 3750, and Synthesis, 1980, 695. Typical reactions involve theaddition of 1 equivalent of a compound of Formula VII to a solution of1.1 to 4 equivalents of titanium tetrachloride, with 1.5 to 2.5equivalents being preferred, and 2.1 to 6 equivalents of sodiumborohydride with 3.5-4.5 equivalents being preferred.

Conventional organic solvents such as ether, tetrahydrofuran,dimethoxyethane, methylene chloride and chloroform can be used with1,2-dimethoxyethane being preferred. The reaction can be conducted attemperatures ranging from -70° C. to 50° C. with -10° C. to 30° C. beingpreferred. The reaction time can be 0.1 hour to 48 hours with 2 to 4hours being preferred. ##STR25##

Formula I (Q-7, W-1) compounds where R is not equal to H can be preparedin the same fashion as described for Formula I (Q-7, W-1) compoundswhere R is not equal to H. Compounds of Formula VII can be prepared asdescribed with respect to Scheme 5.

Compounds of Formula I (Q-8, W-1) can be prepared by a titaniumtetrachloride/sodium borohydride reduction of Formula XIV analogs in asimilar fashion as described for Formula I (Q-7, W-1) compounds. Scheme22 illustrates the method utilized. ##STR26##

The compounds of Formula XIV can be prepared as described with respectto Scheme 11. The compounds represented by Formula I (Q-9, W-1) can beprepared by a titanium tetrachloride/sodium borohydride reduction ofFormula XVII analogs in a similar fashion as described for Formula I(Q-7, W-1) compounds. Scheme 23 illustrates this method. ##STR27##

The preparation of the compounds represented by Formula XVIII is known.The compounds represented by Formula I (Q-10, W-1) can be prepared by atitanium tetrachloride/sodium borohydride reduction of Formula XIXanalogs in a similar fashion as described for Formula I (Q-7, W-1)compounds. Scheme 24 illustrates this method. ##STR28##

The preparation of the compounds represented by Formula XIX is known.The Formula I (Q-6, Q-7, Q-8, Q-9, Q-10, W-1) compounds where Y is otherthan H, can be prepared via the TiCl₄ /NaBH₄ reductive methods describedpreviously.

The preparation of compounds of Formula XIX is a known intramoleculardipolar cycloaddition reaction to generate the pyrazoline nucleus.Compounds of Formulas I where Y¹ and Y are other than H can be preparedby conventional alkylation, acylation and sulfenylation methods known toone skilled in the art.

The following Examples further illustrate the invention.

EXAMPLE 1

Step A: 4-Chloro-2-(3-methyl-2-methylenebutoxy)benzaldehyde

To a solution of 8.8 g (0.064 mol) of potassium carbonate in 100 mL ofdimethylformamide was added 10.0 g (0.064 mol) of4-chlorosalicylaldehyde and 12.5 g (0.077 mol) of2-(bromomethyl)-3-methyl-1-butene. The reaction mixture was heated at70° C. for 2 hours, cooled to room temperature and poured into 600 mLice/water. The crude mixture was extracted with ethyl acetate (3×100mL). The ethyl acetate was washed with water (100 mL) and brine (100mL), dried over anhydrous magnesium sulfate, filtered and concentratedunder reduced pressure to afford 14.0 g of a yellow oil.

200 MHz ¹ H NMR (CDCl₃) δ1.15 (d, 6H), 2.4 (m, 1H), 4.61 (s, 2H), 5.08(s, 1H), 5.15 (s, 1H), 6.99 (s, 1H), 7.02 (d, 1H), 7.80 (d, 1H), 10.5(s, 1H).

IR (neat): 1685 cm⁻¹.

Step B: Diethyl [[4-chloro-2-(3-methyl-2-methylenebutoxy)phenyl]methylene]phosphorohydrazidate

To a solution of 11.8 g (0.070 mol) of diethyl phosphorohydrazidate in140 mL ether was added 14.0 g (0.058 mol) of the product obtained inStep A. The reaction was stirred at room temperature for 30 minutes. Theresultant precipitate was filtered and washed with ether (50 mL) anddried to afford 15.0 g of a white solid, mp 103° C. to 106° C.

200 MHz ¹ H NMR (CDCl₃) δ 1.15 (d, 6H), 1.35 (t, 6H), 2.45 (m, 1H), 4.2(m, 4H), 4.52 (s, 2H), 5.06 (s, 1H), 5.10 (s, 1H), 6.9 (m, 3H), 7.80 (d,1H), 8.1 (s, 1H).

IR (mineral oil): 3140, 1600, 1020 cm⁻¹.

Step C:7-Chloro-2,3,3a,4-tetrahydro-3a-(1-methylethyl)-N-[4-(trifluoromethyl)phenyl][1]benzopyrano[4,3-c]pyrazole-2-carboxamide

To a solution of 6.8 g (0.017 mol) of the product obtained in Step Bdissolved in 90 mL methylene chloride was added 2.8 g (0.021 mol) ofN-chlorosuccinimide. The reaction mixture was stirred at roomtemperature and 2.7 g (0.026 mol) of triethylamine dissolved in 20 mLmethylene chloride was added dropwise over 1 hour. The reaction mixturewas extracted with a 5% HCl solution (100 mL) and washed with water (100mL), dried over anhydrous magnesium sulfate, filtered and concentratedunder reduced pressure to afford 6.3 g of a red oil. This oil was takenup in 60 mL of methanol and 4.9 mL of concentrated HCl was added. Thereaction mixture was refluxed for 3 hours, cooled and concentrated underreduced pressure. 200 mL of a saturated sodium bicarbonate solution wasadded and the reaction mixture was extracted with ethyl acetate (3×100mL). The ethyl acetate was washed with brine (100 mL), dried overanhydrous magnesium sulfate and filtered into a flask where 3.0 g (0.016mol) of α,α,α-trifluoro-p-tolylisocyanate was added. The reactionmixture was stirred at room temperature for 30 minutes, concentratedunder reduced pressure to afford a yellow solid. The yellow solid waschromatographed on silica gel using tetrahydrofuran (20%) and hexanes(80%) as the eluent which afforded 6.4 g of a white solid, mp 150° C. to152° C. 200 MHz ¹ H NMR (CDCl₃) δ 0.82 (d, 3H), 1.1 (d, 3H), 2.11 (m,1H), 3.45 (d, 1H), 4.10 (d, 1H), 4.15 (d, 1H), 4.63 (d, 1H), 6.98 (s,1H), 7.0 (d, 1H), 7.60 (ABq, 4H), 7.75 (d, 1H), 8.11 (s, 1H).

IR (mineral oil): 3390, 1685 cm⁻¹.

Step D:7-Chloro-2,3,3a,4-tetrahydro-3a-(1-methylethyl)-N-[4-(trifluoromethyl)phenyl][1]-benzopyrano[4,3-c]pyrazole-2-carboximidoylchloride

To 0.50 g (0.0012 mol) of the product obtained in Step C in 20 mL ofbenzene was added 0.25 g (0.0012 mol) of phosphorous pentachloride. Thereaction mixture was refluxed for 42 hours, cooled to room temperature,poured into a saturated solution of sodium bicarbonate (100 mL) andextracted with ethyl acetate (3×50 mL). The ethyl acetate was washedwith brine (100 mL), dried over anhydrous magnesium sulfate, filteredand concentrated under reduced pressure to afford an off-white solid.The solid was chromatographed on silica gel using ethyl acetate (15%)and hexanes (85%) as eluents which yielded 0.04 g of a white solid, mp148° C. to 149° C.

200 MHz ¹ H NMR (CDCl₃) δ 0.88 (d, 3H), 1.1 (d, 3H), 2.15 (m, 1H), 3.6(d, 1H), 4.16 (t, 2H), 4.60 (d, 1H), 7.0 (m, 4H), 7.60 (d, 2H), 7.78 (d,1H)

EXAMPLE 2

Step A: 2-Phenyl-1-[4-(trifluoromethyl)phenyl]ethanone

To a solution of 45.0 g of 1-bromo-4-(trifluoromethyl)benzene in 300 mLof THF cooled to -78° C. was added 77.0 mL of 2.5M n-butyl lithium inhexane dropwise. An exothermic reaction to -55° C. was observed. Thereaction was then stirred for 20 minutes after which time phenylacetaldehyde (23.5 mL, 0.2 mol) was added dropwise. The reaction wasthen stirred for an additional hour with gradual warming to roomtemperature. The mixture was then partitioned between ether and water,dried over anhydrous magnesium sulfate and concentrated to 52.6 g of ayellow oil. The crude oil was dissolved in 600 mL of methylene chlorideand 100 g of pyridinium dichromate was added in several portions over 20minutes and the mixture was then stirred at room temperature overnight.The reaction was then diluted with ether and filtered through magnesiumsulfate and concentrated. The crude product was dissolved in hot n-butylchloride, insoluble material was filtered off and the mixture was cooledto 0° C. Filtration and drying of the precipitate afforded 12.7 g of thetitle compound as a white solid, mp 127°-128° C.

¹ H NMR (CDCl₃) δ 4.30 (s, 2H), 7.3 (m), 7.75 (d, 2H), 8.16 (d, 2H).

Step B: 4,5-Dihydro-4-phenyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazole

A mixture of 12.0 g of the compound from Step A, 13.0 mL of 37%formaldehyde, 0.5 mL of piperidine and 0.5 mL of glaciel acetic acid in100 mL of methanol were combined and heated at reflux for 3 hours. Thereaction was then concentrated and the crude product partitioned betweenchloroform and water. The chloroform extracts were dried over anhydroussodium sulfate, filtered and concentrated. The residue was taken up inabout 35 mL of ethanol, 4.0 mL of hydrazine hydrate was added and themixture was heated at reflux for 4 hours. The reaction was then cooledto 0° C. and the precipitated product was filtered and dried to afford6.65 g of the title compound as a white solid, mp 98°-112° C.

¹ H NMR (CDCl₃) δ 3.60 (dd, 1H), 4.04 (t, 1H), 4.56 (dd, 1H), 7.1-7.8(m).

Step C:N-(4-Chlorophenyl)-4,5-dihydro-4-phenyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazole-1-carbothioamide

A mixture of 0.7 g of the compound from Step B and 0.41 g of4-chlorophenyl isothiocyanate were combined in a solvent mixture of 2 mLmethylene chloride and 5 mL ether. After stirring overnight theprecipitated solids were filtered and dried to afford 0.69 g of thetitle compound as a white solid, mp 208°-210° C.

¹ H NMR (CDCl₃) δ 4.46 (m, 1H), 4.80 (m, 2H), 7.2-7.4 (m), 7.6 (m), 7.78(d, 2H), 8.60 (s, 1H).

Step D:N-(4-Chlorophenyl)-4,5-dihydro-α-(methylthio)-4-phenyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazole-1-methanimine

A mixture of 0.54 g of the compound from Step C and 0.1 mL ofiodomethane were stirred overnight after which time the precipitatedsolids were filtered and dried. This product was suspended in 2 mL ofchloroform and 2 mL of 5% aqueous sodium bicarbonate was added. Afterstirring overnight the layers were separated and the chloroform extractsdried over magnesium sulfate and concentrated to afford 0.12 g of thetitle compound as a yellow oil.

¹ H NMR (CDCl₃) δ 2.39 (s, 3H), 3.95 (dd, 1H), 4.40 (t, 1H), 4.70 (dd,1H), 6.84 (d, 1H), 7.2-7.4 (m), 7.54 (d, 2H), 7.78 (d, 2H).

EXAMPLE 31-(4-Chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboximidoylchloride

To a solution of 2.50 g (0.0054 mol) of1-(4-chlorophenyl)-5-(4-fluorophenyl)-N-[4-(trifluoromethyl)-phenyl]-1H-pyrazole-3-carboxamidedissolved in 15 mL of acetonitrile was added 1.80 g (0.0067 mol) oftriphenylphosphine and 0.83 g (0.0054 mol) of carbon tetrachloride. Theyellow solution was stirred at room temperature overnight andconcentrated to afford 4.0 g of a yellow solid. The crude product waschromatographed on silica gel using ethyl acetate (10%) and hexanes(90%) as eluents which afforded 0.64 g of a yellow solid, mp 154° C. to156° C.

200 MHz ¹ H NMR (CDCl₃) δ 3.2 (m, 1H), 3.85 (m, 1H), 5.50 (m, 1H),7.0-7.4 (m, 10H), 7.65 (m, 2H).

IR (mineral oil): 1640, 1610 cm⁻¹.

EXAMPLE 4

1-(4-Chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-N'-hydroxy-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboximidamide

To a solution of 1.0 g (0.002 mol) of the product from Example 3dissolved in 25 mL chloroform was added 0.217 g (0.0031 mol) ofhydroxylamine hydrochloride and 0.525 g (0.0052 mol) of triethylamine.The reaction mixture was refluxed for 18 hours, cooled and ethyl acetate(150 mL) was added and water (100 mL). The organic phase was washed withwater (100 mL) and brine (100 mL), dried over anhydrous magnesiumsulfate, filtered and concentrated under reduced pressure to afford ayellow solid. The crude solid was chromatographed on silica gel usingethyl acetate (20%) and hexanes (80%) as eluent to afford 0.50 g of awhite solid, mp 188° C. to 191° C.

200 MHz ¹ H NMR (CDCl₃) δ 2.89 (m, 1H), 3.78 (m, 1H), 5.50 (m, 1H),6.75-7.5 (m, 12H), 8.6 (bs, 1H), 11.3 (bs, 1H).

IR (mineral oil): 3360, 3300 cm⁻¹.

EXAMPLE 51-(4-Chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-N'-[[(methylamino)carbonyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboximidamide

To a solution of 0.75 g (0.0015 mol) of the product obtained fromExample 4 dissolved in 15 mL tetrahydrofuran was added 0.097 g (0.0017mol) of methyl isocyanate and 0.20 g (0.002 mol) of triethylamine. Thereaction mixture was stirred at room temperature for 18 hours, pouredinto cold water (50 mL) and extracted with ethyl acetate (3×50 mL). Theethyl acetate layer was washed with brine (100 mL), dried over anhydrousmagnesium sulfate, filtered and concentrated under reduced pressure toafford 0.44 g of a white solid, mp 75° C. to 77° C.

200 MHz ¹ H NMR (CDCl₃) δ 2.92 (d, 3H), 3.1 (s, 1H), 3.75 (m, 1H), 5.25(m, 1H), 6.2 (bs, 1H), 6.5 (m, 2H), 7.0-7.6 (m, 11H).

IR (mineral oil): 3300, 1740 cm ⁻¹.

EXAMPLE 6

Step A: Methyl 2-[(2-formylphenoxy)methyl]-2-propenoate

To a solution of 3.8 g (0.0279 mol) of potassium carbonate in 90 mL ofdimethylformamide at room temperature was added 3.4 g (0.0279 mol) ofsalicylaldehyde and 5.0 g (0.0279 mol) of methyl(2-bromomethyl)acrylate. The reaction mixture was heated at 70° C. for 2hours, cooled to room temperature and poured into 400 mL ice water. Awhite solid precipitated and was filtered, rinsed with water (100 mL),dried, rinsed with hexanes (100 mL) and dried to afford 3.85 g of awhite powder; mp 50°-52° C.

200 MHz ¹ H NMR (CDCl₃): δ 3.83 (s, 3H), 4.88 (s, 2H), 6.05 (s, 1H),6.45 (s, 1H), 7.1 (m, 2H), 7.55 (t, 1H), 7.85 (d, 1H), 10.52 (s, 1H).

IR (mineral oil): 1730, 1700 cm⁻¹.

Step B: Methyl1,2,3,3a,4,9b-hexahydro-2[[[4-(trifluoromethyl)phenyl]amino]carbonyl][1]benzopyrano[4,3-c]pyrazole-3a-carboxylate

A solution of 7.15 g (0.0681 mol) of hydrazine dihydrochloride in 95 mLof tert-butanol and 5 mL of water was heated at reflux for 1/2 hour atwhich time 1.50 g (0.0068 mol) of the product from Step A was added allat once. The reaction mixture was refluxed for 20 hours and the solventwas removed by evaporation under reduced pressure. 200 mL of 1N sodiumhydroxide was added and the crude product was extracted with ethylacetate (3×75 mL). The ethyl acetate was washed with water (100 mL),dried over anhydrous magnesium sulfate, filtered into a flask containing1.27 g (0.0068 mol) of α,α,α-trifluoro-p-tolylisocyanate. The reactionmixture was stirred at room temperature for 1/2 hour, the solvent wasremoved under reduced pressure and the crude product was chromatographedusing ether/hexanes (35%:65%) as eluent to afford 0.219 g of a whitesolid; mp 211°-212° C.

200 MHz ¹ H NMR(CDCl₃): δ3.64 (s, 3H), 3.8 (q, 2H), 4.11 (d, 1H), 4.32(d, 1H), 5.04 (d, 1H), 5.50 (d, 1H), 6.9 (t, 1H), 6.95 (t, 1H), 7.2 (m,2H), 7.6 (ABq, 4H), 8.57 (s, 1H).

IR (mineral oil): 3390, 3250, 1748, 1690 cm⁻¹.

EXAMPLE 7 Methyl1,2,3,3a,4,9b-hexahydro-1-[(methylamino)carbonyl]-2-[[[4-(trifluoromethyl)phenyl]amino]carbonyl][1]benzopyrano[4,3-c]pyrazole-3a-carboxylate

The product (0.125 g, 0.000296 mol) of Example 6, Step B was dissolvedin 5 mL ether and 0.023 g of methyl isocyanate was added and stirred for30 min. Three drops of triethylamine was added and the reaction wasstirred for 18 hours at room temperature. A white precipitate hadformed, was filtered, rinsed with ether and dried to afford 0.075 g of awhite solid; mp 208°-209° C.

200 MHz ¹ H NMR(CDCl₃): δ 2.93 (s, 3H), 3.30 (d, 1H), 3.34 (s, 3H), 4.41(d, 1H), 4.83 (d, 1H), 4.99 (d, 1H), 5.07 (s, 1H), 6.1 (q, 1H), 6.78 (d,1H), 6.98 (t, 1H), 7.15 (t, 1H), 7.50 (m, 1H), 7.55 (ABq, 4H), 8.15 (s,1H).

IR (mineral oil): 3360-3260, 1740, 1650 cm⁻¹.

EXAMPLE 83,4-Bis(4-chlorophenyl)-N-[4-(trifluoromethyl)phenyl]-1-pyrazolidinecarboxamide

To a solution of 0.473 g (0.0025 mol) of titanium tetrachloride in 10 mLof 1,2-dimethoxyethane was added 0.189 g (0.0048 mol) of sodiumborohydride all at once at 0° C. The green solution was stirred at 0° C.for 5 minutes and 0.500 g (0.0012 mol) of3,4-bis(4-chlorophenyl)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-1-carboxamidedissolved in 5 mL of 1,2-dimethoxyethane was added dropwise over 5minutes. The cooling bath was removed and the dark brown solution wasstirred at room temperature for 3 hours. The crude reaction mixture waspoured into 100 mL of saturated sodium bicarbonate solution andextracted with ethyl acetate (3×50 mL). The ethyl acetate was washedwith brine (100 mL), dried over anhydrous magnesium sulfate, filteredand the solvent was removed under reduced pressure to afford a yellowsolid. The crude reaction product was chromatographed on silica gel withethyl acetate/hexanes (40%:60%) as eluent and afforded 0.140 g of thetitle compound as a white solid; mp 242°-243° C.

200 MHz ¹ H NMR(CDCl₃): δ 3.90 (m, 2H), 4.22 (dd, 1H), 4.48 (dd, 1H),4.70 (d, 1H), 6.68 (d, 2H), 6.81 (d, 2H), 7.18 (m, 4H), 7.6 (ABq, 4H),8.58 (s, 1H).

IR (mineral oil): 3330, 3220, 1650 cm⁻¹.

EXAMPLE 91-(4-Chlorophenyl)-5-(4-fluorophenyl)-N-[4-(trifluoromethyl)phenyl]-3-pyrazolidinecarboxamide

The title compound (0.040 g) was obtained by reduction of1-(4-chlorophenyl)-5-(4-fluorophenyl)-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamidevia the procedure described in Example 8, (mp 50°-55° C.).

200 MHz ¹ H NMR (CDCl₃) δ 2.7 (m, 1H), 2.9-3.2 (m, 1H), 3.8 (dd, 1H),4.4 (m, 2H), 5.4 (dd, 1H), 6.7-7.8 (m, 12H), 8.6 s, 1/3H), 9.2 (s,2/3H).

IR (mineral oil) 3350, 1660 cm⁻¹.

By the general procedures described herein, or obvious modificationsthereof, the compounds of Tables 1 through 36 can be prepared.

    ______________________________________                                        GENERAL STRUCTURES FOR TABLES 1-36                                            Table    Q                                                                    ______________________________________                                         ##STR29##                                                                     1       Q-1 (R.sup.3  = Me)                                                   2       Q-1 (R.sup.3  = iPr)                                                  3       Q-1 (R.sup.3  = CO.sub.2 Me)                                          4       Q-1 (R.sup.3  = 4-FPh)                                                5       Q-1 (R.sup.3  = 4-ClPh)                                               6       Q-2 (V = O)                                                           7       Q-3 (A = CH.sub.2, Y.sup.1  = H)                                      8       Q-3 (A = O, Y.sup.1  = H)                                             9       Q-4                                                                  10       Q-5                                                                   ##STR30##                                                                     ##STR31##                                                                    12       Q-1 (R.sup.3  = Me)                                                  13       Q-1 (R.sup.3  = iPr)                                                 14       Q-1 (R.sup.3  = CO.sub.2 Me)                                         15       Q-1 (R.sup.3  = 4-FPh)                                               16       Q-1 (R.sup.3  = 4-ClPh)                                              17       Q-1 (V = O)                                                          18       Q-2 (V = O)                                                          19       Q-3 (A = CH.sub.2, R.sup.5  = H, Y.sup.1  = H)                       20       Q-3 (A = O, R.sup.5  = H, Y.sup.1  = H)                              21       Q-5                                                                   ##STR32##                                                                    22       Q-6 (R.sup.3  = Me, R = H, X = O)                                    23       Q-6 (R.sup.3  = iPr, R = H, X = O)                                   24       Q-6 (R.sup.3  = CO.sub.2 Me, R = H, X = O)                           25       Q-6 (R.sup.3  =  4-FPh, R = H, X = O)                                26       Q-6 (R.sup.3  = 4-ClPh, R = H, X = O)                                27       Q-6 (R.sup.3  = Me, R = Me, X = O)                                   28       Q-6 (R.sup.3  = iPr, R = Me, X = O)                                  29       Q-6 (R.sup.3  = CO.sub.2 Me, R = Me, X = O)                          30       Q-6 (R.sup.3  = 4-FPh, R = Me, X = O)                                31       Q-6 (R.sup.3  = 4-ClPh, R = Me, X = O)                               32       Q-7 (R = H, X = O)                                                   33       Q-8 (A = CH.sub.2, Y.sup.1  = H, R = H, X = O)                       34       Q-8 (A = O, Y.sup.1  = H, R = H, X = O)                              35       Q-9 (R = H, X = O)                                                   36       Q-10 (R = H, X = O)                                                  ______________________________________                                    

For the Tables that follow, the values of Q-1 through Q-10 will benumbered as shown. ##STR33##

                                      TABLE 1                                     __________________________________________________________________________    R.sup.1                                                                            R.sup.2                                                                           V    X.sup.1                                                                            R.sup.1                                                                            R.sup.2                                                                            V    X.sup.1                                     __________________________________________________________________________    4-CF.sub.3                                                                         7-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         6-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         6-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-F O    Cl   4-OCF.sub.3                                                                        7-F  O    Cl                                          4-CF.sub.3                                                                         7-F O    OMe  4-OCF.sub.3                                                                        7-F  O    OMe                                         4-CF.sub.3                                                                         7-F O    SMe  4-OCF.sub.3                                                                        7-F  O    SMe                                         4-CF.sub.3                                                                         7-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              O    Cl   4-OCF.sub.3                                                                        7-Cl O    Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              O    OMe  4-OCF.sub.3                                                                        7-Cl O    OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    SMe  4-OCF.sub.3                                                                        7-Cl O    SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                   4-CF.sub.3                                                                         6-F O    Cl   4-OCF.sub.3                                                                        6-F  O    Cl                                          4-CF.sub.3                                                                         6-F O    OMe  4-OCF.sub.3                                                                        6-F  O    OMe                                         4-CF.sub.3                                                                         6-F O    SMe  4-OCF.sub.3                                                                        6-F  O    SMe                                         4-CF.sub.3                                                                         6-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-F NMe  Cl   4-OCF.sub.3                                                                        7-F  NMe  Cl                                          4-CF.sub.3                                                                         7-F NMe  OMe  4-OCF.sub.3                                                                        7-F  NMe  OMe                                         4-CF.sub.3                                                                         7-F NMe  SMe  4-OCF.sub.3                                                                        7-F  NMe  SMe                                         4-CF.sub.3                                                                         7-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NMe  Cl   4-OCF.sub.3                                                                        7-Cl NMe  Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NMe  OMe  4-OCF.sub.3                                                                        7-Cl NMe  OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  SMe  4-OCF.sub.3                                                                        7-Cl NMe  SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                   4-CF.sub.3                                                                         6-F NMe  Cl   4-OCF.sub.3                                                                        6-F  NMe  Cl                                          4-CF.sub.3                                                                         6-F NMe  OMe  4-OCF.sub.3                                                                        6-F  NMe  OMe                                         4-CF.sub.3                                                                         6-F NMe  SMe  4-OCF.sub.3                                                                        6-F  NMe  SMe                                         4-CF.sub.3                                                                         6-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   __________________________________________________________________________

                                      TABLE 2                                     __________________________________________________________________________    R.sup.1                                                                            R.sup.2                                                                           V    X.sup.1                                                                            R.sup.1                                                                            R.sup.2                                                                            V    X.sup.1                                     __________________________________________________________________________    4-CF.sub.3                                                                         7-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         6-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         6-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-F O    Cl   4-OCF.sub.3                                                                        7-F  O    Cl                                          4-CF.sub.3                                                                         7-F O    OMe  4-OCF.sub.3                                                                        7-F  O    OMe                                         4-CF.sub.3                                                                         7-F O    SMe  4-OCF.sub.3                                                                        7-F  O    SMe                                         4-CF.sub.3                                                                         7-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              O    Cl   4-OCF.sub.3                                                                        7-Cl O    Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              O    OMe  4-OCF.sub.3                                                                        7-Cl O    OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    SMe  4-OCF.sub.3                                                                        7-Cl O    SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                   4-CF.sub.3                                                                         6-F O    Cl   4-OCF.sub.3                                                                        6-F  O    Cl                                          4-CF.sub.3                                                                         6-F O    OMe  4-OCF.sub.3                                                                        6-F  O    OMe                                         4-CF.sub.3                                                                         6-F O    SMe  4-OCF.sub.3                                                                        6-F  O    SMe                                         4-CF.sub.3                                                                         6-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-F NMe  Cl   4-OCF.sub.3                                                                        7-F  NMe  Cl                                          4-CF.sub.3                                                                         7-F NMe  OMe  4-OCF.sub.3                                                                        7-F  NMe  OMe                                         4-CF.sub.3                                                                         7-F NMe  SMe  4-OCF.sub.3                                                                        7-F  NMe  SMe                                         4-CF.sub.3                                                                         7-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NMe  Cl   4-OCF.sub.3                                                                        7-Cl NMe  Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NMe  OMe  4-OCF.sub.3                                                                        7-Cl NMe  OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  SMe  4-OCF.sub.3                                                                        7-Cl NMe  SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                   4-CF.sub.3                                                                         6-F NMe  Cl   4-OCF.sub.3                                                                        6-F  NMe  Cl                                          4-CF.sub.3                                                                         6-F NMe  OMe  4-OCF.sub.3                                                                        6-F  NMe  OMe                                         4-CF.sub.3                                                                         6-F NMe  SMe  4-OCF.sub.3                                                                        6-F  NMe  SMe                                         4-CF.sub.3                                                                         6-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   __________________________________________________________________________

                                      TABLE 3                                     __________________________________________________________________________    R.sup.1                                                                            R.sup.2                                                                           V    X.sup.1                                                                            R.sup.1                                                                            R.sup.2                                                                            V    X.sup.1                                     __________________________________________________________________________    4-CF.sub.3                                                                         7-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         6-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         6-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-F O    Cl   4-OCF.sub.3                                                                        7-F  O    Cl                                          4-CF.sub.3                                                                         7-F O    OMe  4-OCF.sub.3                                                                        7-F  O    OMe                                         4-CF.sub.3                                                                         7-F O    SMe  4-OCF.sub.3                                                                        7-F  O    SMe                                         4-CF.sub.3                                                                         7-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              O    Cl   4-OCF.sub.3                                                                        7-Cl O    Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              O    OMe  4-OCF.sub.3                                                                        7-Cl O    OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    SMe  4-OCF.sub.3                                                                        7-Cl O    SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    OCO.sub.2 Me                                                                       4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OCO.sub.2 Me                                4-CF.sub.3                                                                         6-F O    Cl   4-OCF.sub.3                                                                        6-F  O    Cl                                          4-CF.sub.3                                                                         6-F O    OMe  4-OCF.sub.3                                                                        6-F  O    OMe                                         4-CF.sub.3                                                                         6-F O    SMe  4-OCF.sub.3                                                                        6-F  O    SMe                                         4-CF.sub.3                                                                         6-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-F NMe  Cl   4-OCF.sub.3                                                                        7-F  NMe  Cl                                          4-CF.sub.3                                                                         7-F NMe  OMe  4-OCF.sub.3                                                                        7-F  NMe  OMe                                         4-CF.sub.3                                                                         7-F NMe  SMe  4-OCF.sub.3                                                                        7-F  NMe  SMe                                         4-CF.sub.3                                                                         7-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NMe  Cl   4-OCF.sub.3                                                                        7-Cl NMe  Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NMe  OMe  4-OCF.sub.3                                                                        7-Cl NMe  OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  SMe  4-OCF.sub.3                                                                        7-Cl NMe  SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                   4-CF.sub.3                                                                         6-F NMe  Cl   4-OCF.sub.3                                                                        6-F  NMe  Cl                                          4-CF.sub.3                                                                         6-F NMe  OMe  4-OCF.sub.3                                                                        6-F  NMe  OMe                                         4-CF.sub.3                                                                         6-F NMe  SMe  4-OCF.sub.3                                                                        6-F  NMe  SMe                                         4-CF.sub.3                                                                         6-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub. 3                                                                       6-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   __________________________________________________________________________

                                      TABLE 4                                     __________________________________________________________________________    R.sup.1                                                                            R.sup.2                                                                           V    X.sup.1                                                                            R.sup.1                                                                            R.sup.2                                                                            V    X.sup.1                                     __________________________________________________________________________    4-CF.sub.3                                                                         7-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         6-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         6-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-F O    Cl   4-OCF.sub.3                                                                        7-F  O    Cl                                          4-CF.sub.3                                                                         7-F O    OMe  4-OCF.sub.3                                                                        7-F  O    OMe                                         4-CF.sub.3                                                                         7-F O    SMe  4-OCF.sub.3                                                                        7-F  O    SMe                                         4-CF.sub.3                                                                         7-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              O    Cl   4-OCF.sub.3                                                                        7-Cl O    Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              O    OMe  4-OCF.sub.3                                                                        7-Cl O    OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    SMe  4-OCF.sub.3                                                                        7-Cl O    SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                   4-CF.sub.3                                                                         6-F O    Cl   4-OCF.sub.3                                                                        6-F  O    Cl                                          4-CF.sub.3                                                                         6-F O    OMe  4-OCF.sub.3                                                                        6-F  O    OMe                                         4-CF.sub.3                                                                         6-F O    SMe  4-OCF.sub.3                                                                        6-F  O    SMe                                         4-CF.sub.3                                                                         6-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-F NMe  Cl   4-OCF.sub.3                                                                        7-F  NMe  Cl                                          4-CF.sub.3                                                                         7-F NMe  OMe  4-OCF.sub.3                                                                        7-F  NMe  OMe                                         4-CF.sub.3                                                                         7-F NMe  SMe  4-OCF.sub.3                                                                        7-F  NMe  SMe                                         4-CF.sub.3                                                                         7-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NMe  Cl   4-OCF.sub.3                                                                        7-Cl NMe  Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NMe  OMe  4-OCF.sub.3                                                                        7-Cl NMe  OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  SMe  4-OCF.sub.3                                                                        7-Cl NMe  SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                   4-CF.sub.3                                                                         6-F NMe  Cl   4-OCF.sub.3                                                                        6-F  NMe  Cl                                          4-CF.sub.3                                                                         6-F NMe  OMe  4-OCF.sub.3                                                                        6-F  NMe  OMe                                         4-CF.sub.3                                                                         6-F NMe  SMe  4-OCF.sub.3                                                                        6-F  NMe  SMe                                         4-CF.sub.3                                                                         6-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   __________________________________________________________________________

                                      TABLE 5                                     __________________________________________________________________________    R.sup.1                                                                            R.sup.2                                                                           V    X.sup.1                                                                            R.sup.1                                                                            R.sup.2                                                                            V    X.sup.1                                     __________________________________________________________________________    4-CF.sub.3                                                                         7-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         6-F CH.sub.2                                                                           Cl   4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           Cl                                          4-CF.sub.3                                                                         6-F CH.sub.2                                                                           OMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           SMe  4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           SMe                                         4-CF.sub.3                                                                         6-F CH.sub.2                                                                           NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                   4-CF.sub.3                                                                         7-F O    Cl   4-OCF.sub.3                                                                        7-F  O    Cl                                          4-CF.sub.3                                                                         7-F O    OMe  4-OCF.sub.3                                                                        7-F  O    OMe                                         4-CF.sub.3                                                                         7-F O    SMe  4-OCF.sub.3                                                                        7-F  O    SMe                                         4-CF.sub.3                                                                         7-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              O    Cl   4-OCF.sub.3                                                                        7-Cl O    Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              O    OMe  4-OCF.sub.3                                                                        7-Cl O    OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    SMe  4-OCF.sub.3                                                                        7-Cl O    SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                   4-CF.sub.3                                                                         6-F O    Cl   4-OCF.sub.3                                                                        6-F  O    Cl                                          4-CF.sub.3                                                                         6-F O    OMe  4-OCF.sub.3                                                                        6-F  O    OMe                                         4-CF.sub.3                                                                         6-F O    SMe  4-OCF.sub.3                                                                        6-F  O    SMe                                         4-CF.sub.3                                                                         6-F O    NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                   4-CF.sub.3                                                                         7-F NMe  Cl   4-OCF.sub.3                                                                        7-F  NMe  Cl                                          4-CF.sub.3                                                                         7-F NMe  OMe  4-OCF.sub.3                                                                        7-F  NMe  OMe                                         4-CF.sub.3                                                                         7-F NMe  SMe  4-OCF.sub.3                                                                        7-F  NMe  SMe                                         4-CF.sub.3                                                                         7-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NMe  Cl   4-OCF.sub.3                                                                        7-Cl NMe  Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NMe  OMe  4-OCF.sub.3                                                                        7-Cl NMe  OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  SMe  4-OCF.sub.3                                                                        7-Cl NMe  SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                   4-CF.sub.3                                                                         6-F NMe  Cl   4-OCF.sub.3                                                                        6-F  NMe  Cl                                          4-CF.sub.3                                                                         6-F NMe  OMe  4-OCF.sub.3                                                                        6-F  NMe  OMe                                         4-CF.sub.3                                                                         6-F NMe  SMe  4-OCF.sub.3                                                                        6-F  NMe  SMe                                         4-CF.sub.3                                                                         6-F NMe  NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                   4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-Cl                                                                              NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         7-CF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                   4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       Cl   4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       Cl                                          4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       OMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       SMe  4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       SMe                                         4-CF.sub.3                                                                         6-F NSO.sub.2 Me                                                                       NMe.sub.2                                                                          4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                   __________________________________________________________________________

                  TABLE 6                                                         ______________________________________                                        R.sup.1                                                                             R.sup.2                                                                              R.sup.3 X.sup.1                                                                             R.sup.1                                                                              R.sup.2                                                                            R.sup.3                                                                             X.sup.1                          ______________________________________                                        4-CF.sub.3                                                                          7-F    CO.sub.2 Me                                                                           Cl    4-OCF.sub.3                                                                          7-F  CO.sub.2 Me                                                                         Cl                               4-CF.sub.3                                                                          7-F    CO.sub.2 Me                                                                           OMe   4-OCF.sub.3                                                                          7-F  CO.sub.2 Me                                                                         OMe                              4-CF.sub.3                                                                          7-F    CO.sub.2 Me                                                                           SMe   4-OCF.sub.3                                                                          7-F  CO.sub.2 Me                                                                         SMe                              4-CF.sub.3                                                                          7-F    CO.sub.2 Me                                                                           NMe.sub.2                                                                           4-OCF.sub.3                                                                          7-F  CO.sub.2 Me                                                                         NMe.sub.2                        4-CF.sub.3                                                                          7-Cl   CO.sub.2 Me                                                                           Cl    4-OCF.sub.3                                                                          7-Cl CO.sub.2 Me                                                                         Cl                               4-CF.sub.3                                                                          7-Cl   CO.sub.2 Me                                                                           OMe   4-OCF.sub.3                                                                          7-Cl CO.sub.2 Me                                                                         OMe                              4-CF.sub.3                                                                          7-Cl   CO.sub.2 Me                                                                           SMe   4-OCF.sub.3                                                                          7-Cl CO.sub.2 Me                                                                         SMe                              4-CF.sub.3                                                                          7-Cl   CO.sub.2 Me                                                                           NMe.sub.2                                                                           4-OCF.sub.3                                                                          7-Cl CO.sub.2 Me                                                                         NMe.sub.2                        4-CF.sub.3                                                                          7-F    4-F-Ph  Cl    4-OCF.sub.3                                                                          7-F  4-F-Ph                                                                              Cl                               4-CF.sub.3                                                                          7-F    4-F-Ph  OMe   4-OCF.sub.3                                                                          7-F  4-F-Ph                                                                              OMe                              4-CF.sub.3                                                                          7-F    4-F-Ph  SMe   4-OCF.sub.3                                                                          7-F  4-F-Ph                                                                              SMe                              4-CF.sub.3                                                                          7-F    4-F-Ph  NMe.sub.2                                                                           4-OCF.sub.3                                                                          7-F  4-F-Ph                                                                              NMe.sub.2                        4-CF.sub.3                                                                          7-Cl   4-F-Ph  Cl    4-OCF.sub.3                                                                          7-Cl 4-F-Ph                                                                              Cl                               4-CF.sub.3                                                                          7-Cl   4-F-Ph  OMe   4-OCF.sub.3                                                                          7-Cl 4-F-Ph                                                                              OMe                              4-CF.sub.3                                                                          7-Cl   4-F-Ph  SMe   4-OCF.sub.3                                                                          7-Cl 4-F-Ph                                                                              SMe                              4-CF.sub.3                                                                          7-Cl   4-F-Ph  NMe.sub.2                                                                           4-OCF.sub.3                                                                          7-Cl 4-F-Ph                                                                              NMe.sub.2                        ______________________________________                                    

                                      TABLE 7                                     __________________________________________________________________________    R.sup.1                                                                           R.sup.2                                                                            R.sup.4                                                                            X.sup.1                                                                           R.sup.1                                                                            R.sup.2                                                                            R.sup.4                                                                            X.sup.1                                      __________________________________________________________________________    4-CF.sub.3                                                                        5-F  Me   Cl  4-OCF.sub.3                                                                        5-F  Me   Cl                                           4-CF.sub.3                                                                        5-F  iPr  Cl  4-OCF.sub.3                                                                        5-F  iPr  Cl                                           4-CF.sub.3                                                                        5-F  Ph   Cl  4-OCF.sub.3                                                                        5-F  Ph   Cl                                           4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        5-Cl Me   Cl  4-OCF.sub.3                                                                        5-Cl Me   Cl                                           4-CF.sub.3                                                                        5-Cl iPr  Cl  4-OCF.sub.3                                                                        5-Cl iPr  Cl                                           4-CF.sub.3                                                                        5-Cl Ph   Cl  4-OCF.sub.3                                                                        5-Cl Ph   Cl                                           4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        4-F  Me   Cl  4-OCF.sub.3                                                                        4-F  Me   Cl                                           4-CF.sub.3                                                                        4-F  iPr  Cl  4-OCF.sub.3                                                                        4-F  iPr  Cl                                           4-CF.sub.3                                                                        4-F  Ph   Cl  4-OCF.sub.3                                                                        4-F  Ph   Cl                                           4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        5-F  Me   OMe 4-OCF.sub.3                                                                        5-F  Me   OMe                                          4-CF.sub.3                                                                        5-F  iPr  OMe 4-OCF.sub.3                                                                        5-F  iPr  OMe                                          4-CF.sub.3                                                                        5-F  Ph   OMe 4-OCF.sub.3                                                                        5-F  Ph   OMe                                          4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        5-Cl Me   OMe 4-OCF.sub.3                                                                        5-Cl Me   OMe                                          4-CF.sub.3                                                                        5-Cl iPr  OMe 4-OCF.sub.3                                                                        5-Cl iPr  OMe                                          4-CF.sub.3                                                                        5-Cl Ph   OMe 4-OCF.sub.3                                                                        5-Cl Ph   OMe                                          4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        4-F  Me   OMe 4-OCF.sub.3                                                                        4-F  Me   OMe                                          4-CF.sub.3                                                                        4-F  iPr  OMe 4-OCF.sub.3                                                                        4-F  iPr  OMe                                          4-CF.sub.3                                                                        4-F  Ph   OMe 4-OCF.sub.3                                                                        4-F  Ph   OMe                                          4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        5-F  Me   SMe 4-OCF.sub.3                                                                        5-F  Me   SMe                                          4-CF.sub.3                                                                        5-F  iPr  SMe 4-OCF.sub.3                                                                        5-F  iPr  SMe                                          4-CF.sub.3                                                                        5-F  Ph   SMe 4-OCF.sub.3                                                                        5-F  Ph   SMe                                          4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        5-Cl Me   SMe 4-OCF.sub.3                                                                        5-Cl Me   SMe                                          4-CF.sub.3                                                                        5-Cl iPr  SMe 4-OCF.sub.3                                                                        5-Cl iPr  SMe                                          4-CF.sub.3                                                                        5-Cl Ph   SMe 4-OCF.sub.3                                                                        5-Cl Ph   SMe                                          4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        4-F  Me   SMe 4-OCF.sub.3                                                                        4-F  Me   SMe                                          4-CF.sub.3                                                                        4-F  iPr  SMe 4-OCF.sub.3                                                                        4-F  iPr  SMe                                          4-CF.sub.3                                                                        4-F  Ph   SMe 4-OCF.sub.3                                                                        4-F  Ph   SMe                                          4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        5-F  Me   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  Me   NMe.sub.2                                    4-CF.sub.3                                                                        5-F  iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  iPr  NMe.sub.2                                    4-CF.sub.3                                                                        5-F  Ph   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  Ph   NMe.sub.2                                    4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl Me   NMe.sub. 2                                                                        4-OCF.sub.3                                                                        5-Cl Me   NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-Cl iPr  NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl Ph   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-Cl Ph   NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            NMe.sub.2                                    4-CF.sub.3                                                                        4-F  Me   NMe.sub.2                                                                         4-OCF.sub.3                                                                        4-F  Me   NMe.sub.2                                    4-CF.sub.3                                                                        4-F  iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        4-F  iPr  NMe.sub.2                                    4-CF.sub.3                                                                        4-F  Ph   NMe.sub.2                                                                         4-OCF.sub.3                                                                        4-F  Ph   NMe.sub.2                                    4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             NMe.sub. 2                                                                        4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            NMe.sub.2                                    __________________________________________________________________________

                                      TABLE 8                                     __________________________________________________________________________    R.sup.1                                                                           R.sup.2                                                                            R.sup.4                                                                            X.sup.1                                                                           R.sup.1                                                                            R.sup.2                                                                            R.sup.4                                                                            X.sup.1                                      __________________________________________________________________________    4-CF.sub.3                                                                        5-F  Me   Cl  4-OCF.sub.3                                                                        5-F  Me   Cl                                           4-CF.sub.3                                                                        5-F  iPr  Cl  4-OCF.sub.3                                                                        5-F  iPr  Cl                                           4-CF.sub.3                                                                        5-F  Ph   Cl  4-OCF.sub.3                                                                        5-F  Ph   Cl                                           4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        5-Cl Me   Cl  4-OCF.sub.3                                                                        5-Cl Me   Cl                                           4-CF.sub.3                                                                        5-Cl iPr  Cl  4-OCF.sub.3                                                                        5-Cl iPr  Cl                                           4-CF.sub.3                                                                        5-Cl Ph   Cl  4-OCF.sub.3                                                                        5-Cl Ph   Cl                                           4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        4-F  Me   Cl  4-OCF.sub.3                                                                        4-F  Me   Cl                                           4-CF.sub.3                                                                        4-F  iPr  Cl  4-OCF.sub.3                                                                        4-F  iPr  Cl                                           4-CF.sub.3                                                                        4-F  Ph   Cl  4-OCF.sub.3                                                                        4-F  Ph   Cl                                           4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             Cl  4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             Cl                                           4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            Cl  4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            Cl                                           4-CF.sub.3                                                                        5-F  Me   OMe 4-OCF.sub.3                                                                        5-F  Me   OMe                                          4-CF.sub.3                                                                        5-F  iPr  OMe 4-OCF.sub.3                                                                        5-F  iPr  OMe                                          4-CF.sub.3                                                                        5-F  Ph   OMe 4-OCF.sub.3                                                                        5-F  Ph   OMe                                          4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        5-Cl Me   OMe 4-OCF.sub.3                                                                        5-Cl Me   OMe                                          4-CF.sub.3                                                                        5-Cl iPr  OMe 4-OCF.sub.3                                                                        5-Cl iPr  OMe                                          4-CF.sub.3                                                                        5-Cl Ph   OMe 4-OCF.sub.3                                                                        5-Cl Ph   OMe                                          4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        4-F  Me   OMe 4-OCF.sub.3                                                                        4-F  Me   OMe                                          4-CF.sub.3                                                                        4-F  iPr  OMe 4-OCF.sub.3                                                                        4-F  iPr  OMe                                          4-CF.sub.3                                                                        4-F  Ph   OMe 4-OCF.sub.3                                                                        4-F  Ph   OMe                                          4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             OMe 4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             OMe                                          4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OMe 4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OMe                                          4-CF.sub.3                                                                        5-F  Me   SMe 4-OCF.sub.3                                                                        5-F  Me   SMe                                          4-CF.sub.3                                                                        5-F  iPr  SMe 4-OCF.sub.3                                                                        5-F  iPr  SMe                                          4-CF.sub.3                                                                        5-F  Ph   SMe 4-OCF.sub.3                                                                        5-F  Ph   SMe                                          4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        5-Cl Me   SMe 4-OCF.sub.3                                                                        5-Cl Me   SMe                                          4-CF.sub.3                                                                        5-Cl iPr  SMe 4-OCF.sub.3                                                                        5-Cl iPr  SMe                                          4-CF.sub.3                                                                        5-Cl Ph   SMe 4-OCF.sub.3                                                                        5-Cl Ph   SMe                                          4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        4-F  Me   SMe 4-OCF.sub.3                                                                        4-F  Me   SMe                                          4-CF.sub.3                                                                        4-F  iPr  SMe 4-OCF.sub.3                                                                        4-F  iPr  SMe                                          4-CF.sub.3                                                                        4-F  Ph   SMe 4-OCF.sub.3                                                                        4-F  Ph   SMe                                          4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             SMe 4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             SMe                                          4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            SMe 4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            SMe                                          4-CF.sub.3                                                                        5-F  Me   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  Me   NMe.sub.2                                    4-CF.sub.3                                                                        5-F  iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  iPr  NMe.sub.2                                    4-CF.sub.3                                                                        5-F  Ph   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  Ph   NMe.sub.2                                    4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl Me   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-Cl Me   NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-Cl iPr  NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl Ph   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-Cl Ph   NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   NMe.sub. 2                                                                        4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            NMe.sub.2                                    4-CF.sub.3                                                                        4-F  Me   NMe.sub.2                                                                         4-OCF.sub.3                                                                        4-F  Me   NMe.sub.2                                    4-CF.sub.3                                                                        4-F  iPr  NMe.sub.2                                                                         4-OCF.sub.3                                                                        4-F  iPr  NMe.sub.2                                    4-CF.sub.3                                                                        4-F  Ph   NMe.sub.2                                                                         4-OCF.sub.3                                                                        4-F  Ph   NMe.sub.2                                    4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             NMe.sub.2                                                                         4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             NMe.sub.2                                    4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            NMe.sub.2                                                                         4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            NMe.sub.2                                    __________________________________________________________________________

                                      TABLE 9                                     __________________________________________________________________________    R.sup.1                                                                            R.sup.2                                                                           R.sup.3                                                                            R.sup.5                                                                         X.sup.1                                                                           R.sup.1                                                                            R.sup.2                                                                           R.sup.3                                                                            R.sup.45                                                                         X.sup.1                                  __________________________________________________________________________    4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H Cl  4-OCF.sub.3                                                                        4-Cl                                                                              4-Cl-Ph                                                                            H  NMe.sub.2                                4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H OMe 4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me Cl                                       4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H SMe 4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me OMe                                      4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H NMe.sub.2                                                                         4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me SMe                                      4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H Cl  4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me NMe.sub.2                                4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OMe 4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me Cl                                       4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H SMe 4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OMe                                      4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H NMe.sub.2                                                                         4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me SMe                                      4-CF.sub.3                                                                         4-Cl                                                                              4-Cl-Ph                                                                            H Cl  4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me NMe.sub.2                                4-CF.sub.3                                                                         4-Cl                                                                              4-Cl-Ph                                                                            H OMe 4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me Cl                                       4-CF.sub.3                                                                         4-Cl                                                                              4-Cl-Ph                                                                            H SMe 4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me OMe                                      4-CF.sub.3                                                                         4-Cl                                                                              4-Cl-Ph                                                                            H NMe.sub.2                                                                         4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me SMe                                      4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-Cl-Ph                                                                            H Cl  4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me NMe.sub.2                                4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-Cl-Ph                                                                            H OMe 4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me Cl                                       4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-Cl-Ph                                                                            H SMe 4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OMe                                      4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-Cl-Ph                                                                            H NMe.sub.2                                                                         4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me SMe                                      4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H Cl  4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me NMe.sub.2                                4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H OMe                                                           4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H SMe                                                           4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H NMe.sub.2                                                     4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H Cl                                                            4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OMe                                                           4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H SMe                                                           4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H NMe.sub.2                                                     4-OCF.sub.3                                                                        4-Cl                                                                              4-Cl-Ph                                                                            H Cl                                                            4-OCF.sub.3                                                                        4-Cl                                                                              4-Cl-Ph                                                                            H OMe                                                           4-OCF.sub.3                                                                        4-Cl                                                                              4-Cl-Ph                                                                            H SMe                                                           __________________________________________________________________________

                                      TABLE 10                                    __________________________________________________________________________    R.sup.1                                                                            R.sup.2                                                                           R.sup.3                                                                            R.sup.5                                                                         X.sup.1                                                                           R.sup.1                                                                            R.sup.2                                                                           R.sup.3                                                                            R.sup.5                                                                          X.sup.1                                  __________________________________________________________________________    4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H Cl  4-OCF.sub.3                                                                        4-CF.sub.3                                                                        4-F-Ph                                                                             H  NMe.sub.2                                4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H OMe 4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me Cl                                       4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H SMe 4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me OMe                                      4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H NMe.sub.2                                                                         4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me SMe                                      4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H Cl  4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me NMe.sub.2                                4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OMe 4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me Cl                                       4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H SMe 4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OMe                                      4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H NMe.sub.2                                                                         4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me SMe                                      4-CF.sub.3                                                                         4-Cl                                                                              4-F-Ph                                                                             H Cl  4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me NMe.sub.2                                4-CF.sub.3                                                                         4-Cl                                                                              4-F-Ph                                                                             H OMe 4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me Cl                                       4-CF.sub.3                                                                         4-Cl                                                                              4-F-Ph                                                                             H SMe 4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me OMe                                      4-CF.sub.3                                                                         4-Cl                                                                              4-F-Ph                                                                             H NMe.sub.2                                                                         4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me SMe                                      4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-F-Ph                                                                             H Cl  4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me NMe.sub.2                                4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-F-Ph                                                                             H OMe 4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me Cl                                       4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-F-Ph                                                                             H SMe 4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OMe                                      4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-F-Ph                                                                             H NMe.sub.2                                                                         4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me SMe                                      4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H Cl  4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me NMe.sub.2                                4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H OMe                                                           4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H SMe                                                           4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H NMe.sub.2                                                     4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H Cl                                                            4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OMe                                                           4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H SMe                                                           4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H NMe.sub.2                                                     4-OCF.sub.3                                                                        4-Cl                                                                              4-F-Ph                                                                             H Cl                                                            4-OCF.sub.3                                                                        4-Cl                                                                              4-F-Ph                                                                             H OMe                                                           4-OCF.sub.3                                                                        4-Cl                                                                              4-F-Ph                                                                             H SMe                                                           4-OCF.sub.3                                                                        4-Cl                                                                              4-F-Ph                                                                             H NMe.sub.2                                                     4-OCF.sub.3                                                                        4-CF.sub.3                                                                        4-F-Ph                                                                             H Cl                                                            4-OCF.sub.3                                                                        4-CF.sub.3                                                                        4-F-Ph                                                                             H OMe                                                           4-OCF.sub.3                                                                        4-CF.sub.3                                                                        4-F-Ph                                                                             H SMe                                                           __________________________________________________________________________

                                      TABLE 11                                    __________________________________________________________________________    R.sup.2                                                                          R.sup.3                                                                         X.sup.1       R.sup.2                                                                           R.sup.3                                                                            X.sup.1                                           __________________________________________________________________________    4-Cl                                                                             iPr                                                                             SCH.sub.2 Ph  4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCH.sub.2 Ph                                      4-Cl                                                                             iPr                                                                             SCH.sub.2 CHCH.sub.2                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCH.sub.2 CHCH.sub.2                              4-Cl                                                                             iPr                                                                             SCH.sub.2 CCH 4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCH.sub.2 CCH                                     4-Cl                                                                             iPr                                                                             SCF.sub.3     4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCF.sub.3                                         4-Cl                                                                             iPr                                                                             SCH.sub.2 CF.sub.3                                                                          4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCH.sub.2 CF.sub.3                                4-Cl                                                                             iPr                                                                             SCH.sub.2 CO.sub.2 Me                                                                       4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCH.sub.2 CO.sub.2 Me                             4-Cl                                                                             iPr                                                                             SCH.sub.2 CN  4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCH.sub.2 CN                                      4-Cl                                                                             iPr                                                                             SCH.sub.2 NO.sub.2                                                                          4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCH.sub.2 NO.sub.2                                4-Cl                                                                             iPr                                                                             SCH.sub.2 CH.sub.2 OMe                                                                      4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCH.sub.2 CH.sub.2 OMe                            4-Cl                                                                             iPr                                                                             SCH.sub.2 CH.sub.2 SMe                                                                      4-CF.sub.3                                                                        CO.sub.2 Me                                                                        SCH.sub.2 CH.sub.2 SMe                            4-Cl                                                                             iPr                                                                             OCH.sub.2 Ph  4-CF.sub.3                                                                        CO.sub.2 Me                                                                        OCH.sub.2 Ph                                      4-Cl                                                                             iPr                                                                             OCH.sub.2 CHCH.sub.2                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        OCH.sub.2 CHCH.sub.2                              4-Cl                                                                             iPr                                                                             OCH.sub.2 CCH 4-CF.sub.3                                                                        CO.sub.2 Me                                                                        OCH.sub.2 CCH                                     4-Cl                                                                             iPr                                                                             OCH.sub.2 CF.sub.3                                                                          4-CF.sub.3                                                                        CO.sub.2 Me                                                                        OCH.sub.2 CF.sub.3                                4-Cl                                                                             iPr                                                                             OCH.sub.2 CO.sub.2 Me                                                                       4-CF.sub.3                                                                        CO.sub.2 Me                                                                        OCH.sub.2 CO.sub.2 Me                             4-Cl                                                                             iPr                                                                             OCH.sub.2 CN  4-CF.sub.3                                                                        CO.sub.2 Me                                                                        OCH.sub.2 CN                                      4-Cl                                                                             iPr                                                                             OCH.sub.2 CH.sub.2 OMe                                                                      4-CF.sub.3                                                                        CO.sub.2 Me                                                                        OCH.sub.2 CH.sub.2 OMe                            4-Cl                                                                             iPr                                                                             OCH.sub.2 CH.sub.2 SMe                                                                      4-CF.sub.3                                                                        CO.sub.2 Me                                                                        OCH.sub.2 CH.sub.2 SMe                            4-Cl                                                                             iPr                                                                             NMe.sub.2     4-CF.sub.3                                                                        CO.sub.2 Me                                                                        NMe.sub.2                                         4-Cl                                                                             iPr                                                                             NH-4-Cl-Ph    4-CF.sub.3                                                                        CO.sub.2 Me                                                                        NH-4-Cl-Ph                                        4-Cl                                                                             iPr                                                                             NH-4-CF.sub.3 -Ph                                                                           4-CF.sub.3                                                                        CO.sub.2 Me                                                                        NH-4-CF.sub.3 -Ph                                 4-Cl                                                                             iPr                                                                             N(CH.sub.2).sub.4                                                                           4-CF.sub.3                                                                        CO.sub.2 Me                                                                        N(CH.sub.2).sub.4                                 4-Cl                                                                             iPr                                                                             N(CH.sub.2).sub.5                                                                           4-CF.sub.3                                                                        CO.sub.2 Me                                                                        N(CH.sub.2).sub.5                                 4-Cl                                                                             iPr                                                                             N(--CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 --)                                                4-CF.sub.3                                                                        CO.sub.2 Me                                                                        N(--CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2          __________________________________________________________________________                                --)                                           

                                      TABLE 12                                    __________________________________________________________________________    R.sup.1                                                                           R.sup.2                                                                            V    X.sup.2                                                                              R.sup.1                                                                            R.sup.2                                                                            V    X.sup.2                                   __________________________________________________________________________    4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-F  O    OH     4-OCF.sub.3                                                                        7-F  O    OH                                        4-CF.sub.3                                                                        7-F  O    OMe    4-OCF.sub.3                                                                        7-F  O    OMe                                       4-CF.sub.3                                                                        7-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  O    OCONHMe                                   4-CF.sub.3                                                                        7-F  O    CN     4-OCF.sub. 3                                                                       7-F  O    CN                                        4-CF.sub.3                                                                        7-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl O    OH     4-OCF.sub.3                                                                        7-Cl O    OH                                        4-CF.sub.3                                                                        7-Cl O    OMe    4-OCF.sub.3                                                                        7-Cl O    OMe                                       4-CF.sub.3                                                                        7-Cl O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl O    OCONHMe                                   4-CF.sub.3                                                                        7-Cl O    CN     4-OCF.sub.3                                                                        7-Cl O    CN                                        4-CF.sub.3                                                                        7-Cl O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                 4-CF.sub.3                                                                        6-F  O    OH     4-OCF.sub.3                                                                        6-F  O    OH                                        4-CF.sub.3                                                                        6-F  O    OMe    4-OCF.sub.3                                                                        6-F  O    OMe                                       4-CF.sub.3                                                                        6-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  O    OCONHMe                                   4-CF.sub.3                                                                        6-F  O    CN     4-OCF.sub.3                                                                        6-F  O    CN                                        4-CF.sub.3                                                                        6-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NMe  OH     4-OCF.sub.3                                                                        7-F  NMe  OH                                        4-CF.sub.3                                                                        7-F  NMe  OMe    4-OCF.sub.3                                                                        7-F  NMe  OMe                                       4-CF.sub.3                                                                        7-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        7-F  NMe  CN     4-OCF.sub.3                                                                        7-F  NMe  CN                                        4-CF.sub.3                                                                        7-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NMe  OH     4-OCF.sub.3                                                                        7-Cl NMe  OH                                        4-CF.sub.3                                                                        7-Cl NMe  OMe    4-OCF.sub.3                                                                        7-Cl NMe  OMe                                       4-CF.sub.3                                                                        7-Cl NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NMe  OCONHMe                                   4-CF.sub.3                                                                        7-Cl NMe  CN     4-OCF.sub.3                                                                        7-Cl NMe  CN                                        4-CF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NMe  OH     4-OCF.sub.3                                                                        6-F  NMe  OH                                        4-CF.sub.3                                                                        6-F  NMe  OMe    4-OCF.sub.3                                                                        6-F  NMe  OMe                                       4-CF.sub.3                                                                        6-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        6-F  NMe  CN     4-OCF.sub.3                                                                        6-F  NMe  CN                                        4-CF.sub.3                                                                        6-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NSO.sub. 2 Me                                                                      OH     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 __________________________________________________________________________

                                      TABLE 13                                    __________________________________________________________________________    R.sup.1                                                                           R.sup.2                                                                            V    X.sup.2                                                                              R.sup.1                                                                            R.sup.2                                                                            V    X.sup.2                                   __________________________________________________________________________    4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-F  O    OH     4-OCF.sub.3                                                                        7-F  O    OH                                        4-CF.sub.3                                                                        7-F  O    OMe    4-OCF.sub.3                                                                        7-F  O    OMe                                       4-CF.sub.3                                                                        7-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  O    OCONHMe                                   4-CF.sub.3                                                                        7-F  O    CN     4-OCF.sub. 3                                                                       7-F  O    CN                                        4-CF.sub.3                                                                        7-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl O    OH     4-OCF.sub.3                                                                        7-Cl O    OH                                        4-CF.sub.3                                                                        7-Cl O    OMe    4-OCF.sub.3                                                                        7-Cl O    OMe                                       4-CF.sub.3                                                                        7-Cl O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl O    OCONHMe                                   4-CF.sub.3                                                                        7-Cl O    CN     4-OCF.sub.3                                                                        7-Cl O    CN                                        4-CF.sub.3                                                                        7-Cl O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                 4-CF.sub.3                                                                        6-F  O    OH     4-OCF.sub.3                                                                        6-F  O    OH                                        4-CF.sub.3                                                                        6-F  O    OMe    4-OCF.sub.3                                                                        6-F  O    OMe                                       4-CF.sub.3                                                                        6-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  O    OCONHMe                                   4-CF.sub.3                                                                        6-F  O    CN     4-OCF.sub.3                                                                        6-F  O    CN                                        4-CF.sub.3                                                                        6-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NMe  OH     4-OCF.sub.3                                                                        7-F  NMe  OH                                        4-CF.sub.3                                                                        7-F  NMe  OMe    4-OCF.sub.3                                                                        7-F  NMe  OMe                                       4-CF.sub.3                                                                        7-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        7-F  NMe  CN     4-OCF.sub.3                                                                        7-F  NMe  CN                                        4-CF.sub.3                                                                        7-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NMe  OH     4-OCF.sub.3                                                                        7-Cl NMe  OH                                        4-CF.sub.3                                                                        7-Cl NMe  OMe    4-OCF.sub.3                                                                        7-Cl NMe  OMe                                       4-CF.sub.3                                                                        7-Cl NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NMe  OCONHMe                                   4-CF.sub.3                                                                        7-Cl NMe  CN     4-OCF.sub.3                                                                        7-Cl NMe  CN                                        4-CF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NMe  OH     4-OCF.sub.3                                                                        6-F  NMe  OH                                        4-CF.sub.3                                                                        6-F  NMe  OMe    4-OCF.sub.3                                                                        6-F  NMe  OMe                                       4-CF.sub.3                                                                        6-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        6-F  NMe  CN     4-OCF.sub.3                                                                        6-F  NMe  CN                                        4-CF.sub.3                                                                        6-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NSO.sub. 2 Me                                                                      OH     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 __________________________________________________________________________

                                      TABLE 14                                    __________________________________________________________________________    R.sup.1                                                                           R.sup.2                                                                            V    X.sup.2                                                                              R.sup.1                                                                            R.sup.2                                                                            V    X.sup.2                                   __________________________________________________________________________    4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-F  O    OH     4-OCF.sub.3                                                                        7-F  O    OH                                        4-CF.sub.3                                                                        7-F  O    OMe    4-OCF.sub.3                                                                        7-F  O    OMe                                       4-CF.sub.3                                                                        7-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  O    OCONHMe                                   4-CF.sub.3                                                                        7-F  O    CN     4-OCF.sub. 3                                                                       7-F  O    CN                                        4-CF.sub.3                                                                        7-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl O    OH     4-OCF.sub.3                                                                        7-Cl O    OH                                        4-CF.sub.3                                                                        7-Cl O    OMe    4-OCF.sub.3                                                                        7-Cl O    OMe                                       4-CF.sub.3                                                                        7-Cl O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl O    OCONHMe                                   4-CF.sub.3                                                                        7-Cl O    CN     4-OCF.sub.3                                                                        7-Cl O    CN                                        4-CF.sub.3                                                                        7-Cl O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                 4-CF.sub.3                                                                        6-F  O    OH     4-OCF.sub.3                                                                        6-F  O    OH                                        4-CF.sub.3                                                                        6-F  O    OMe    4-OCF.sub.3                                                                        6-F  O    OMe                                       4-CF.sub.3                                                                        6-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  O    OCONHMe                                   4-CF.sub.3                                                                        6-F  O    CN     4-OCF.sub.3                                                                        6-F  O    CN                                        4-CF.sub.3                                                                        6-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NMe  OH     4-OCF.sub.3                                                                        7-F  NMe  OH                                        4-CF.sub.3                                                                        7-F  NMe  OMe    4-OCF.sub.3                                                                        7-F  NMe  OMe                                       4-CF.sub.3                                                                        7-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        7-F  NMe  CN     4-OCF.sub.3                                                                        7-F  NMe  CN                                        4-CF.sub.3                                                                        7-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NMe  OH     4-OCF.sub.3                                                                        7-Cl NMe  OH                                        4-CF.sub.3                                                                        7-Cl NMe  OMe    4-OCF.sub.3                                                                        7-Cl NMe  OMe                                       4-CF.sub.3                                                                        7-Cl NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NMe  OCONHMe                                   4-CF.sub.3                                                                        7-Cl NMe  CN     4-OCF.sub.3                                                                        7-Cl NMe  CN                                        4-CF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NMe  OH     4-OCF.sub.3                                                                        6-F  NMe  OH                                        4-CF.sub.3                                                                        6-F  NMe  OMe    4-OCF.sub.3                                                                        6-F  NMe  OMe                                       4-CF.sub.3                                                                        6-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        6-F  NMe  CN     4-OCF.sub.3                                                                        6-F  NMe  CN                                        4-CF.sub.3                                                                        6-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NSO.sub. 2 Me                                                                      OH     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 __________________________________________________________________________

                                      TABLE 15                                    __________________________________________________________________________    R.sup.1                                                                           R.sup.2                                                                            V    X.sup.2                                                                              R.sup.1                                                                            R.sup.2                                                                            V    X.sup.2                                   __________________________________________________________________________    4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-F  O    OH     4-OCF.sub.3                                                                        7-F  O    OH                                        4-CF.sub.3                                                                        7-F  O    OMe    4-OCF.sub.3                                                                        7-F  O    OMe                                       4-CF.sub.3                                                                        7-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  O    OCONHMe                                   4-CF.sub.3                                                                        7-F  O    CN     4-OCF.sub. 3                                                                       7-F  O    CN                                        4-CF.sub.3                                                                        7-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl O    OH     4-OCF.sub.3                                                                        7-Cl O    OH                                        4-CF.sub.3                                                                        7-Cl O    OMe    4-OCF.sub.3                                                                        7-Cl O    OMe                                       4-CF.sub.3                                                                        7-Cl O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl O    OCONHMe                                   4-CF.sub.3                                                                        7-Cl O    CN     4-OCF.sub.3                                                                        7-Cl O    CN                                        4-CF.sub.3                                                                        7-Cl O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                 4-CF.sub.3                                                                        6-F  O    OH     4-OCF.sub.3                                                                        6-F  O    OH                                        4-CF.sub.3                                                                        6-F  O    OMe    4-OCF.sub.3                                                                        6-F  O    OMe                                       4-CF.sub.3                                                                        6-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  O    OCONHMe                                   4-CF.sub.3                                                                        6-F  O    CN     4-OCF.sub.3                                                                        6-F  O    CN                                        4-CF.sub.3                                                                        6-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NMe  OH     4-OCF.sub.3                                                                        7-F  NMe  OH                                        4-CF.sub.3                                                                        7-F  NMe  OMe    4-OCF.sub.3                                                                        7-F  NMe  OMe                                       4-CF.sub.3                                                                        7-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        7-F  NMe  CN     4-OCF.sub.3                                                                        7-F  NMe  CN                                        4-CF.sub.3                                                                        7-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NMe  OH     4-OCF.sub.3                                                                        7-Cl NMe  OH                                        4-CF.sub.3                                                                        7-Cl NMe  OMe    4-OCF.sub.3                                                                        7-Cl NMe  OMe                                       4-CF.sub.3                                                                        7-Cl NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NMe  OCONHMe                                   4-CF.sub.3                                                                        7-Cl NMe  CN     4-OCF.sub.3                                                                        7-Cl NMe  CN                                        4-CF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NMe  OH     4-OCF.sub.3                                                                        6-F  NMe  OH                                        4-CF.sub.3                                                                        6-F  NMe  OMe    4-OCF.sub.3                                                                        6-F  NMe  OMe                                       4-CF.sub.3                                                                        6-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        6-F  NMe  CN     4-OCF.sub.3                                                                        6-F  NMe  CN                                        4-CF.sub.3                                                                        6-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NSO.sub. 2 Me                                                                      OH     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 __________________________________________________________________________

                                      TABLE 16                                    __________________________________________________________________________    R.sup.1                                                                           R.sup.2                                                                            V    X.sup.2                                                                              R.sup.1                                                                            R.sup.2                                                                            V    X.sup.2                                   __________________________________________________________________________    4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OH     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OH                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe    4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OMe                                       4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           OCONHMe                                   4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           CN     4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           CN                                        4-CF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  CH.sub.2                                                                           NMe.sub.2                                 4-CF.sub.3                                                                        7-F  O    OH     4-OCF.sub.3                                                                        7-F  O    OH                                        4-CF.sub.3                                                                        7-F  O    OMe    4-OCF.sub.3                                                                        7-F  O    OMe                                       4-CF.sub.3                                                                        7-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  O    OCONHMe                                   4-CF.sub.3                                                                        7-F  O    CN     4-OCF.sub. 3                                                                       7-F  O    CN                                        4-CF.sub.3                                                                        7-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl O    OH     4-OCF.sub.3                                                                        7-Cl O    OH                                        4-CF.sub.3                                                                        7-Cl O    OMe    4-OCF.sub.3                                                                        7-Cl O    OMe                                       4-CF.sub.3                                                                        7-Cl O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl O    OCONHMe                                   4-CF.sub.3                                                                        7-Cl O    CN     4-OCF.sub.3                                                                        7-Cl O    CN                                        4-CF.sub.3                                                                        7-Cl O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl O    NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         O    NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        O    NMe.sub.2                                 4-CF.sub.3                                                                        6-F  O    OH     4-OCF.sub.3                                                                        6-F  O    OH                                        4-CF.sub.3                                                                        6-F  O    OMe    4-OCF.sub.3                                                                        6-F  O    OMe                                       4-CF.sub.3                                                                        6-F  O    OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  O    OCONHMe                                   4-CF.sub.3                                                                        6-F  O    CN     4-OCF.sub.3                                                                        6-F  O    CN                                        4-CF.sub.3                                                                        6-F  O    NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  O    NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NMe  OH     4-OCF.sub.3                                                                        7-F  NMe  OH                                        4-CF.sub.3                                                                        7-F  NMe  OMe    4-OCF.sub.3                                                                        7-F  NMe  OMe                                       4-CF.sub.3                                                                        7-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        7-F  NMe  CN     4-OCF.sub.3                                                                        7-F  NMe  CN                                        4-CF.sub.3                                                                        7-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NMe  OH     4-OCF.sub.3                                                                        7-Cl NMe  OH                                        4-CF.sub.3                                                                        7-Cl NMe  OMe    4-OCF.sub.3                                                                        7-Cl NMe  OMe                                       4-CF.sub.3                                                                        7-Cl NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NMe  OCONHMe                                   4-CF.sub.3                                                                        7-Cl NMe  CN     4-OCF.sub.3                                                                        7-Cl NMe  CN                                        4-CF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NMe  NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NMe  OH     4-OCF.sub.3                                                                        6-F  NMe  OH                                        4-CF.sub.3                                                                        6-F  NMe  OMe    4-OCF.sub.3                                                                        6-F  NMe  OMe                                       4-CF.sub.3                                                                        6-F  NMe  OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NMe  OCONHMe                                   4-CF.sub.3                                                                        6-F  NMe  CN     4-OCF.sub.3                                                                        6-F  NMe  CN                                        4-CF.sub.3                                                                        6-F  NMe  NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NMe  NMe.sub.2                                 4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-Cl NSO.sub. 2 Me                                                                      OH     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-Cl NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-CF.sub.3                                                                         NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        7-OCF.sub.3                                                                        NSO.sub.2 Me                                                                       NMe.sub.2                                 4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OH                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe    4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OMe                                       4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                                                              4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       OCONHMe                                   4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN     4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       CN                                        4-CF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                                                            4-OCF.sub.3                                                                        6-F  NSO.sub.2 Me                                                                       NMe.sub.2                                 __________________________________________________________________________

                                      TABLE 17                                    __________________________________________________________________________    R.sup.1                                                                            R.sup.2                                                                         R.sup.3                                                                         X.sup.2   R.sup.1                                                                            R.sup.2                                                                          R.sup.3                                                                            X.sup.2                                       __________________________________________________________________________    4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OCH.sub.2 Ph                                                                            4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OCH.sub.2 Ph                                  4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OCH.sub.2 CHCH.sub.2                                                                    4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OCH.sub.2 CHCH.sub.2                          4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OCH.sub.2 CCH                                                                           4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OCH.sub.2 CCH                                 4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OCONMe.sub.2                                                                            4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OCONMe.sub.2                                  4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OCONH-4-Cl-Ph                                                                           4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OCONH-4-Cl-Ph                                 4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OCONH-4-CF.sub.3 -Ph                                                                    4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OCONH-4-CF.sub.3 -Ph                          4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OCOMe     4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OCOMe                                         4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OCO.sub.2 Me                                                                            4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OCO.sub.2 Me                                  4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             NHMe      4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        NHMe                                          4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             NHCO.sub.2 Me                                                                           4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        NHCO.sub.2 Me                                 4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             NHCH.sub.2 CF.sub.3                                                                     4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        NHCH.sub. 2 CF.sub.3                          4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             NHPh      4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        NHPh                                          4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             NHPy      4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        NHPy                                          4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             NMePh     4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        NMePh                                         4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OSO.sub.2 Me                                                                            4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OSO.sub.2 Me                                  4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OSO.sub.2 Ph                                                                            4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OSO.sub.2 Ph                                  4-CF.sub.3                                                                         Cl                                                                              iPr                                                                             OCSNMe.sub.2                                                                            4-CF.sub.3                                                                         CF.sub.3                                                                         CO.sub.2 Me                                                                        OCSNMe.sub.2                                  4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OCH.sub.2 Ph                                                                            4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OCH.sub.2 Ph                                  4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OCH.sub.2 CHCH.sub.2                                                                    4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OCH.sub.2 CHCH.sub.2                          4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OCH.sub.2 CCH                                                                           4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OCH.sub.2 CCH                                 4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OCONMe.sub.2                                                                            4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OCONMe.sub.2                                  4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OCONH-4-Cl-Ph                                                                           4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OCONH-4-Cl-Ph                                 4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OCONH-4-CF.sub.3 -Ph                                                                    4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OCONH-4-CF.sub.3 -Ph                          4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OCOMe     4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OCOMe                                         4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OCO.sub.2 Me                                                                            4-OCF.sub.3                                                                        CF.sub. 3                                                                        CO.sub.2 Me                                                                        OCO.sub.2 Me                                  4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             NHMe      4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        NHMe                                          4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             NHCO.sub.2 Me                                                                           4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        NHCO.sub.2 Me                                 4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             NHCH.sub.2 CF.sub.3                                                                     4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        NHCH.sub.2 CF.sub.3                           4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             NHPh      4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        NHPh                                          4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             NHPy      4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        NHPy                                          4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             NMePh     4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        NMePh                                         4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OSO.sub.2 Me                                                                            4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OSO.sub.2 Me                                  4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OSO.sub.2 Ph                                                                            4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OSO.sub.2 Ph                                  4-OCF.sub.3                                                                        Cl                                                                              iPr                                                                             OCSNMe.sub.2                                                                            4-OCF.sub.3                                                                        CF.sub.3                                                                         CO.sub.2 Me                                                                        OCSNMe.sub.2                                  __________________________________________________________________________

                  TABLE 18                                                        ______________________________________                                        R.sup.1                                                                             R.sup.2                                                                              R.sup.3 X.sup.2                                                                             R.sup.1                                                                              R.sup.2                                                                            R.sup.3                                                                             X.sup.2                          ______________________________________                                        4-CF.sub.3                                                                          7-F    CO.sub.2 Me                                                                           OH    4-OCF.sub.3                                                                          7-F  CO.sub.2 Me                                                                         OH                               4-CF.sub.3                                                                          7-F    CO.sub.2 Me                                                                           OMe   4-OCF.sub.3                                                                          7-F  CO.sub.2 Me                                                                         OMe                              4-CF.sub.3                                                                          7-F    CO.sub.2 Me                                                                           CN    4-OCF.sub.3                                                                          7-F  CO.sub.2 Me                                                                         CN                               4-CF.sub.3                                                                          7-F    CO.sub.2 Me                                                                           NMe.sub.2                                                                           4-OCF.sub.3                                                                          7-F  CO.sub.2 Me                                                                         NMe.sub.2                        4-CF.sub.3                                                                          7-Cl   CO.sub.2 Me                                                                           OH    4-OCF.sub.3                                                                          7-Cl CO.sub.2 Me                                                                         OH                               4-CF.sub.3                                                                          7-Cl   CO.sub.2 Me                                                                           OMe   4-OCF.sub.3                                                                          7-Cl CO.sub.2 Me                                                                         OMe                              4-CF.sub.3                                                                          7-Cl   CO.sub.2 Me                                                                           CN    4-OCF.sub.3                                                                          7-Cl CO.sub.2 Me                                                                         CN                               4-CF.sub.3                                                                          7-Cl   CO.sub.2 Me                                                                           NMe.sub.2                                                                           4-OCF.sub.3                                                                          7-Cl CO.sub.2 Me                                                                         NMe.sub.2                        4-CF.sub.3                                                                          7-F    4-F-Ph  OH    4-OCF.sub.3                                                                          7-F  4-F-Ph                                                                              OH                               4-CF.sub.3                                                                          7-F    4-F-Ph  OMe   4-OCF.sub.3                                                                          7-F  4-F-Ph                                                                              OMe                              4-CF.sub.3                                                                          7-F    4-F-Ph  CN    4-OCF.sub.3                                                                          7-F  4-F-Ph                                                                              CN                               4-CF.sub.3                                                                          7-F    4-F-Ph  NMe.sub.2                                                                           4-OCF.sub.3                                                                          7-F  4-F-Ph                                                                              NMe.sub.2                        4-CF.sub.3                                                                          7-Cl   4-F-Ph  OH    4-OCF.sub. 3                                                                         7-Cl 4-F-Ph                                                                              OH                               4-CF.sub.3                                                                          7-Cl   4-F-Ph  OMe   4-OCF.sub.3                                                                          7-Cl 4-F-Ph                                                                              OMe                              4-CF.sub.3                                                                          7-Cl   4-F-Ph  CN    4-OCF.sub.3                                                                          7-Cl 4-F-Ph                                                                              CN                               4-CF.sub.3                                                                          7-Cl   4-F-Ph  NMe.sub.2                                                                           4-OCF.sub.3                                                                          7-Cl 4-F-Ph                                                                              NMe.sub.2                        ______________________________________                                    

                                      TABLE 19                                    __________________________________________________________________________    R.sup.1                                                                           R.sup.2                                                                            R.sup.4                                                                            X.sup.2                                                                              R.sup.1                                                                            R.sup.2                                                                            R.sup.4                                                                            X.sup.2                                   __________________________________________________________________________    4-CF.sub.3                                                                        5-F  Me   OH     4-OCF.sub.3                                                                        5-F  Me   OH                                        4-CF.sub.3                                                                        5-F  iPr  OH     4-OCF.sub.3                                                                        5-F  iPr  OH                                        4-CF.sub.3                                                                        5-F  Ph   OH     4-OCF.sub.3                                                                        5-F  Ph   OH                                        4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        5-Cl Me   OH     4-OCF.sub.3                                                                        5-Cl Me   OH                                        4-CF.sub.3                                                                        5-Cl iPr  OH     4-OCF.sub.3                                                                        5-Cl iPr  OH                                        4-CF.sub.3                                                                        5-Cl Ph   OH     4-OCF.sub.3                                                                        5-Cl Ph   OH                                        4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        4-F  Me   OH     4-OCF.sub.3                                                                        4-F  Me   OH                                        4-CF.sub.3                                                                        4-F  iPr  OH     4-OCF.sub.3                                                                        4-F  iPr  OH                                        4-CF.sub.3                                                                        4-F  Ph   OH     4-OCF.sub.3                                                                        4-F  Ph   OH                                        4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        5-F  Me   OMe    4-OCF.sub.3                                                                        5-F  Me   OMe                                       4-CF.sub.3                                                                        5-F  iPr  OMe    4-OCF.sub.3                                                                        5-F  iPr  OMe                                       4-CF.sub.3                                                                        5-F  Ph   OMe    4-OCF.sub.3                                                                        5-F  Ph   OMe                                       4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        5-Cl Me   OMe    4-OCF.sub.3                                                                        5-Cl Me   OMe                                       4-CF.sub.3                                                                        5-Cl iPr  OMe    4-OCF.sub.3                                                                        5-Cl iPr  OMe                                       4-CF.sub.3                                                                        5-Cl Ph   OMe    4-OCF.sub.3                                                                        5-Cl Ph   OMe                                       4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        4-F  Me   OMe    4-OCF.sub.3                                                                        4-F  Me   OMe                                       4-CF.sub.3                                                                        4-F  iPr  OMe    4-OCF.sub.3                                                                        4-F  iPr  OMe                                       4-CF.sub.3                                                                        4-F  Ph   OMe    4-OCF.sub.3                                                                        4-F  Ph   OMe                                       4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        5-F  Me   OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  Me   OCONHMe                                   4-CF.sub.3                                                                        5-F  iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  iPr  OCONHMe                                   4-CF.sub.3                                                                        5-F  Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  Ph   OCONHMe                                   4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        5-Cl Me   OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl Me   OCONHMe                                   4-CF.sub.3                                                                        5-Cl iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl iPr  OCONHMe                                   4-CF.sub.3                                                                        5-Cl Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl Ph   OCONHMe                                   4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        4-F  Me   OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  Me   OCONHMe                                   4-CF.sub.3                                                                        4-F  iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  iPr  OCONHMe                                   4-CF.sub.3                                                                        4-F  Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  Ph   OCONHMe                                   4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        5-F  Me   CN     4-OCF.sub.3                                                                        5-F  Me   CN                                        4-CF.sub.3                                                                        5-F  iPr  CN     4-OCF.sub.3                                                                        5-F  iPr  CN                                        4-CF.sub.3                                                                        5-F  Ph   CN     4-OCF.sub.3                                                                        5-F  Ph   CN                                        4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        5-Cl Me   CN     4-OCF.sub.3                                                                        5-Cl Me   CN                                        4-CF.sub.3                                                                        5-Cl iPr  CN     4-OCF.sub.3                                                                        5-Cl iPr  CN                                        4-CF.sub.3                                                                        5-Cl Ph   CN     4-OCF.sub.3                                                                        5-Cl Ph   CN                                        4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        4-F  Me   CN     4-OCF.sub.3                                                                        4-F  Me   CN                                        4-CF.sub.3                                                                        4-F  iPr  CN     4-OCF.sub.3                                                                        4-F  iPr  CN                                        4-CF.sub.3                                                                        4-F  Ph   CN     4-OCF.sub.3                                                                        4-F  Ph   CN                                        4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        5-F  Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  Me   NMe.sub.2                                 4-CF.sub.3                                                                        5-F  iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  iPr  NMe.sub.2                                 4-CF.sub.3                                                                        5-F  Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  Ph   NMe.sub.2                                 4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl Me   NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl iPr  NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl Ph   NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            NMe.sub.2                                 4-CF.sub.3                                                                        4-F  Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  Me   NMe.sub.2                                 4-CF.sub.3                                                                        4-F  iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  iPr  NMe.sub.2                                 4-CF.sub.3                                                                        4-F  Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  Ph   NMe.sub.2                                 4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            NMe.sub.2                                 __________________________________________________________________________

                                      TABLE 20                                    __________________________________________________________________________    R.sup.1                                                                           R.sup.2                                                                            R.sup.4                                                                            X.sup.2                                                                              R.sup.1                                                                            R.sup.2                                                                            R.sup.4                                                                            X.sup.2                                   __________________________________________________________________________    4-CF.sub.3                                                                        5-F  Me   OH     4-OCF.sub.3                                                                        5-F  Me   OH                                        4-CF.sub.3                                                                        5-F  iPr  OH     4-OCF.sub.3                                                                        5-F  iPr  OH                                        4-CF.sub.3                                                                        5-F  Ph   OH     4-OCF.sub.3                                                                        5-F  Ph   OH                                        4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        5-Cl Me   OH     4-OCF.sub.3                                                                        5-Cl Me   OH                                        4-CF.sub.3                                                                        5-Cl iPr  OH     4-OCF.sub.3                                                                        5-Cl iPr  OH                                        4-CF.sub.3                                                                        5-Cl Ph   OH     4-OCF.sub.3                                                                        5-Cl Ph   OH                                        4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        4-F  Me   OH     4-OCF.sub.3                                                                        4-F  Me   OH                                        4-CF.sub.3                                                                        4-F  iPr  OH     4-OCF.sub.3                                                                        4-F  iPr  OH                                        4-CF.sub.3                                                                        4-F  Ph   OH     4-OCF.sub.3                                                                        4-F  Ph   OH                                        4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             OH     4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             OH                                        4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OH     4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OH                                        4-CF.sub.3                                                                        5-F  Me   OMe    4-OCF.sub.3                                                                        5-F  Me   OMe                                       4-CF.sub.3                                                                        5-F  iPr  OMe    4-OCF.sub.3                                                                        5-F  iPr  OMe                                       4-CF.sub.3                                                                        5-F  Ph   OMe    4-OCF.sub.3                                                                        5-F  Ph   OMe                                       4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        5-Cl Me   OMe    4-OCF.sub.3                                                                        5-Cl Me   OMe                                       4-CF.sub.3                                                                        5-Cl iPr  OMe    4-OCF.sub.3                                                                        5-Cl iPr  OMe                                       4-CF.sub.3                                                                        5-Cl Ph   OMe    4-OCF.sub.3                                                                        5-Cl Ph   OMe                                       4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        4-F  Me   OMe    4-OCF.sub.3                                                                        4-F  Me   OMe                                       4-CF.sub.3                                                                        4-F  iPr  OMe    4-OCF.sub.3                                                                        4-F  iPr  OMe                                       4-CF.sub.3                                                                        4-F  Ph   OMe    4-OCF.sub.3                                                                        4-F  Ph   OMe                                       4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             OMe    4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             OMe                                       4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OMe    4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OMe                                       4-CF.sub.3                                                                        5-F  Me   OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  Me   OCONHMe                                   4-CF.sub.3                                                                        5-F  iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  iPr  OCONHMe                                   4-CF.sub.3                                                                        5-F  Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  Ph   OCONHMe                                   4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        5-Cl Me   OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl Me   OCONHMe                                   4-CF.sub.3                                                                        5-Cl iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl iPr  OCONHMe                                   4-CF.sub.3                                                                        5-Cl Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl Ph   OCONHMe                                   4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        4-F  Me   OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  Me   OCONHMe                                   4-CF.sub.3                                                                        4-F  iPr  OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  iPr  OCONHMe                                   4-CF.sub.3                                                                        4-F  Ph   OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  Ph   OCONHMe                                   4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             OCONHMe                                   4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OCONHMe                                                                              4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            OCONHMe                                   4-CF.sub.3                                                                        5-F  Me   CN     4-OCF.sub.3                                                                        5-F  Me   CN                                        4-CF.sub.3                                                                        5-F  iPr  CN     4-OCF.sub.3                                                                        5-F  iPr  CN                                        4-CF.sub.3                                                                        5-F  Ph   CN     4-OCF.sub.3                                                                        5-F  Ph   CN                                        4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        5-Cl Me   CN     4-OCF.sub.3                                                                        5-Cl Me   CN                                        4-CF.sub.3                                                                        5-Cl iPr  CN     4-OCF.sub.3                                                                        5-Cl iPr  CN                                        4-CF.sub.3                                                                        5-Cl Ph   CN     4-OCF.sub.3                                                                        5-Cl Ph   CN                                        4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        4-F  Me   CN     4-OCF.sub.3                                                                        4-F  Me   CN                                        4-CF.sub.3                                                                        4-F  iPr  CN     4-OCF.sub.3                                                                        4-F  iPr  CN                                        4-CF.sub.3                                                                        4-F  Ph   CN     4-OCF.sub.3                                                                        4-F  Ph   CN                                        4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             CN     4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             CN                                        4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            CN     4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            CN                                        4-CF.sub.3                                                                        5-F  Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  Me   NMe.sub.2                                 4-CF.sub.3                                                                        5-F  iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  iPr  NMe.sub.2                                 4-CF.sub.3                                                                        5-F  Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  Ph   NMe.sub.2                                 4-CF.sub.3                                                                        5-F  4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        5-F  4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-F  4-Cl-Ph                                                                            NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl Me   NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl iPr  NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl Ph   NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl 4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl 4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-Cl 4-Cl-Ph                                                                            NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Me   NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         iPr  NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         Ph   NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-CF.sub.3                                                                         4-Cl-Ph                                                                            NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Me   NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        iPr  NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        Ph   NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        5-OCF.sub.3                                                                        4-Cl-Ph                                                                            NMe.sub.2                                 4-CF.sub.3                                                                        4-F  Me   NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  Me   NMe.sub.2                                 4-CF.sub.3                                                                        4-F  iPr  NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  iPr  NMe.sub.2                                 4-CF.sub.3                                                                        4-F  Ph   NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  Ph   NMe.sub.2                                 4-CF.sub.3                                                                        4-F  4-F-Ph                                                                             NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  4-F-Ph                                                                             NMe.sub.2                                 4-CF.sub.3                                                                        4-F  4-Cl-Ph                                                                            NMe.sub.2                                                                            4-OCF.sub.3                                                                        4-F  4-Cl-Ph                                                                            NMe.sub.2                                 __________________________________________________________________________

                                      TABLE 21                                    __________________________________________________________________________    R.sup.1                                                                            R.sup.2                                                                           R.sup.3                                                                            R.sup.5                                                                         X.sup.2                                                                              R.sup.1                                                                            R.sup.2                                                                           R.sup.3                                                                            R.sup.5                                                                          X.sup.2                               __________________________________________________________________________    4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H OH     4-O-CF.sub.3                                                                       4-Cl                                                                              4-F-Ph                                                                             H  CN                                    4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H OMe    4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me OH                                    4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H OCONHMe                                                                              4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me OMe                                   4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        H CN     4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me OCONHMe                               4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OH     4-CF.sub.3                                                                         4-Cl                                                                              CO.sub.2 Me                                                                        Me CN                                    4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OMe    4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OH                                    4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OCONHMe                                                                              4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OMe                                   4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H CN     4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OCONHMe                               4-CF.sub.3                                                                         4-Cl                                                                              4-F-Ph                                                                             H OH     4-CF.sub.3                                                                         4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me CN                                    4-CF.sub.3                                                                         4-Cl                                                                              4-F-Ph                                                                             H OMe    4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        Me OH                                    4-CF.sub.3                                                                         4-Cl                                                                              4-F-Ph                                                                             H OCONHMe                                                                              4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        Me OMe                                   4-CF.sub.3                                                                         4-Cl                                                                              4-F-Ph                                                                             H CN     4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        Me OCONHMe                               4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-F-Ph                                                                             H OH     4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        Me CN                                    4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-F-Ph                                                                             H OMe    4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OH                                    4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-F-Ph                                                                             H OCONHMe                                                                              4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OMe                                   4-CF.sub.3                                                                         4-CF.sub.3                                                                        4-F-Ph                                                                             H CN     4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me OCONHMe                               4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H OH     4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        Me CN                                    4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H OMe                                                           4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H OCONHMe                                                       4-OCF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        H CN                                                            4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OH                                                            4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OMe                                                           4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H OCONHMe                                                       4-OCF.sub.3                                                                        4-CF.sub.3                                                                        CO.sub.2 Me                                                                        H CN                                                            4-OCF.sub.3                                                                        4-Cl                                                                              4-F-Ph                                                                             H OH                                                            4-OCF.sub.3                                                                        4-Cl                                                                              4-F-Ph                                                                             H OMe                                                           4-OCF.sub.3                                                                        4-Cl                                                                              4-F-Ph                                                                             H OCONHMe                                                       __________________________________________________________________________

                  TABLE 22                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2  V        R.sup.1 R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub. 3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 23                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2  V        R.sup.1 R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub. 3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 24                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2  V        R.sup.1 R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub. 3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 25                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2  V        R.sup.1 R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub. 3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 26                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2  V        R.sup.1 R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub. 3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 27                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2  V        R.sup.1 R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      CH.sub.2 4-OCF.sub.3                                                                           7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl     CH.sub.2 4-OCF.sub.3                                                                           7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                             CH.sub.2 4-OCF.sub.3                                                                           7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F      CH.sub.2 4-OCF.sub.3                                                                           6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-F      O        4-OCF.sub.3                                                                           7-F   O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-Cl     O        4-OCF.sub.3                                                                           7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                             O        4-OCF.sub.3                                                                           7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           6-F      O        4-OCF.sub.3                                                                           6-F   O                                      4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-F      NMe      4-OCF.sub.3                                                                           7-F   NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl     NMe      4-OCF.sub.3                                                                           7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub. 3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                             NMe      4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           6-F      NMe      4-OCF.sub.3                                                                           6-F   NMe                                    4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl     NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                             NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F      NSO.sub.2 Me                                                                           4-OCF.sub.3                                                                           6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 28                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2 V          R.sup.1                                                                              R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub. 3                                                                         7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 29                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2 V          R.sup.1                                                                              R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub. 3                                                                         7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 30                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2 V          R.sup.1                                                                              R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub. 3                                                                         7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 31                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2 V          R.sup.1                                                                              R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     CH.sub.2   4-OCF.sub.3                                                                          7-F   CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-Cl    CH.sub.2   4-OCF.sub.3                                                                          7-Cl  CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           7-CF.sub.3                                                                            CH.sub.2   4-OCF.sub.3                                                                          7-CF.sub.3                                                                          CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           6-F     CH.sub.2   4-OCF.sub.3                                                                          6-F   CH.sub.2                               4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-F     O          4-OCF.sub.3                                                                          7-F   O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-Cl    O          4-OCF.sub.3                                                                          7-Cl  O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           7-CF.sub.3                                                                            O          4-OCF.sub.3                                                                          7-CF.sub.3                                                                          O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           6-F     O          4-OCF.sub.3                                                                          6-F   O                                      4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-F     NMe        4-OCF.sub.3                                                                          7-F   NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-Cl    NMe        4-OCF.sub.3                                                                          7-Cl  NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub. 3                                                                         7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           7-CF.sub.3                                                                            NMe        4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           6-F     NMe        4-OCF.sub.3                                                                          6-F   NMe                                    4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-Cl    NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-Cl  NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub. 3                                                                         NSO.sub.2 Me                           4-CF.sub.3                                                                           7-CF.sub.3                                                                            NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          7-CF.sub.3                                                                          NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           4-CF.sub.3                                                                           6-F     NSO.sub.2 Me                                                                             4-OCF.sub.3                                                                          6-F   NSO.sub.2 Me                           ______________________________________                                    

                  TABLE 32                                                        ______________________________________                                        R.sup.1                                                                              R.sup.2 V          R.sup.1                                                                              R.sup.2                                                                             V                                      ______________________________________                                        4-CF.sub.3                                                                           7-F     CO.sub.2 Me                                                                              4-OCF.sub.3                                                                          7-F   CO.sub.2 Me                            4-CF.sub.3                                                                           7-F     CO.sub.2 Me                                                                              4-OCF.sub.3                                                                          7-F   CO.sub.2 Me                            4-CF.sub.3                                                                           7-F     CO.sub.2 Me                                                                              4-OCF.sub.3                                                                          7-F   CO.sub.2 Me                            4-CF.sub.3                                                                           7-F     CO.sub.2 Me                                                                              4-OCF.sub.3                                                                          7-F   CO.sub.2 Me                            4-CF.sub.3                                                                           7-Cl    CO.sub.2 Me                                                                              4-OCF.sub.3                                                                          7-Cl  CO.sub.2 Me                            4-CF.sub.3                                                                           7-Cl    CO.sub.2 Me                                                                              4-OCF.sub.3                                                                          7-Cl  CO.sub.2 Me                            4-CF.sub.3                                                                           7-Cl    CO.sub.2 Me                                                                              4-OCF.sub.3                                                                          7-Cl  CO.sub.2 Me                            4-CF.sub.3                                                                           7-Cl    CO.sub.2 Me                                                                              4-OCF.sub.3                                                                          7-Cl  CO.sub.2 Me                            4-CF.sub.3                                                                           7-F     4-F--Ph    4-OCF.sub.3                                                                          7-F   4-F--Ph                                4-CF.sub.3                                                                           7-F     4-F--Ph    4-OCF.sub.3                                                                          7-F   4-F--Ph                                4-CF.sub.3                                                                           7-F     4-F--Ph    4-OCF.sub.3                                                                          7-F   4-F--Ph                                4-CF.sub.3                                                                           7-F     4-F--Ph    4-OCF.sub.3                                                                          7-F   4-F--Ph                                4-CF.sub.3                                                                           7-Cl    4-F--Ph    4-OCF.sub.3                                                                          7-Cl  4-F--Ph                                4-CF.sub.3                                                                           7-Cl    4-F--Ph    4-OCF.sub.3                                                                          7-Cl  4-F--Ph                                4-CF.sub.3                                                                           7-Cl    4-F--Ph    4-OCF.sub.3                                                                          7-Cl  4-F--Ph                                4-CF.sub.3                                                                           7-Cl    4-F--Ph    4-OCF.sub.3                                                                          7-Cl  4-F--Ph                                ______________________________________                                    

                  TABLE 33                                                        ______________________________________                                        R.sup.1                                                                             R.sup.2  R.sup.4    R.sup.1                                                                             R.sup.2                                                                              R.sup.4                                ______________________________________                                        4-CF.sub.3                                                                          5-F      Me         4-OCF.sub.3                                                                         5-F    Me                                     4-CF.sub.3                                                                          5-F      iPr        4-OCF.sub.3                                                                         5-F    iPr                                    4-CF.sub.3                                                                          5-F      Ph         4-OCF.sub.3                                                                         5-F    Ph                                     4-CF.sub.3                                                                          5-F      4-F--Ph    4-OCF.sub.3                                                                         5-F    4-F--Ph                                4-CF.sub.3                                                                          5-F      4-Cl--Ph   4-OCF.sub.3                                                                         5-f    4-Cl--Ph                               4-CF.sub.3                                                                          5-Cl     Me         4-OCF.sub.3                                                                         5-Cl   Me                                     4-CF.sub.3                                                                          5-Cl     iPr        4-OCF.sub.3                                                                         5-Cl   iPr                                    4-CF.sub.3                                                                          5-Cl     Ph         4-OCF.sub.3                                                                         5-Cl   Ph                                     4-CF.sub.3                                                                          5-Cl     4-F--Ph    4-OCF.sub.3                                                                         5-Cl   4-F--Ph                                4-CF.sub.3                                                                          5-Cl     4-Cl--Ph   4-OCF.sub.3                                                                         5-Cl   4-Cl--Ph                               4-CF.sub.3                                                                          5-CF.sub.3                                                                             Me         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Me                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             iPr        4-OCF.sub.3                                                                         5-CF.sub.3                                                                           iPr                                    4-CF.sub.3                                                                          5-CF.sub.3                                                                             Ph         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Ph                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-F--Ph    4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-F--Ph                                4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-Cl--Ph   4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-Cl--Ph                               4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Me         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Me                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            iPr        4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          iPr                                    4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Ph         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Ph                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-F--Ph    4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-F--Ph                                4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-Cl--Ph   4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-Cl--Ph                               4-CF.sub.3                                                                          4-F      Me         4-OCF.sub.3                                                                         4-F    Me                                     4-CF.sub.3                                                                          4-F      iPr        4-OCF.sub.3                                                                         4-F    iPr                                    4-CF.sub.3                                                                          4-F      Ph         4-OCF.sub.3                                                                         4-F    Ph                                     4-CF.sub.3                                                                          4-F      4-F--Ph    4-OCF.sub.3                                                                         4-F    4-F--Ph                                4-CF.sub.3                                                                          4-F      4-Cl--Ph   4-OCF.sub.3                                                                         4-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-F      Me         4-OCF.sub.3                                                                         5-F    Me                                     4-CF.sub.3                                                                          5-F      iPr        4-OCF.sub.3                                                                         5-F    iPr                                    4-CF.sub.3                                                                          5-F      Ph         4-OCF.sub.3                                                                         5-F    Ph                                     4-CF.sub.3                                                                          5-F      4-F--Ph    4-OCF.sub.3                                                                         5-F    4-F--Ph                                4-CF.sub.3                                                                          5-F      4-Cl--Ph   4-OCF.sub.3                                                                         5-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-Cl     Me         4-OCF.sub.3                                                                         5-Cl   Me                                     4-CF.sub.3                                                                          5-Cl     iPr        4-OCF.sub.3                                                                         5-Cl   iPr                                    4-CF.sub.3                                                                          5-Cl     Ph         4-OCF.sub.3                                                                         5-Cl   Ph                                     4-CF.sub.3                                                                          5-Cl     4-F--Ph    4-OCF.sub.3                                                                         5-Cl   4-F--Ph                                4-CF.sub.3                                                                          5-Cl     4-Cl--Ph   4-OCF.sub.3                                                                         5-Cl   4-Cl--Ph                               4-CF.sub.3                                                                          5-CF.sub.3                                                                             Me         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Me                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             iPr        4-OCF.sub.3                                                                         5-CF.sub.3                                                                           iPr                                    4-CF.sub.3                                                                          5-CF.sub.3                                                                             Ph         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Ph                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-F--Ph    4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-F--Ph                                4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-Cl--Ph   4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-Cl--Ph                               4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Me         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Me                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            iPr        4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          iPr                                    4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Ph         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Ph                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-F--Ph    4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-F--Ph                                4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-Cl--Ph   4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-Cl--Ph                               4-CF.sub.3                                                                          4-F      Me         4-OCF.sub.3                                                                         4-F    Me                                     4-CF.sub.3                                                                          4-F      iPr        4-OCF.sub.3                                                                         4-F    iPr                                    4-CF.sub.3                                                                          4-F      Ph         4-OCF.sub.3                                                                         4-F    Ph                                     4-CF.sub.3                                                                          4-F      4-F--Ph    4-OCF.sub.3                                                                         4-F    4-F--Ph                                4-CF.sub.3                                                                          4-F      4-Cl--Ph   4-OCF.sub.3                                                                         4-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-F      Me         4-OCF.sub.3                                                                         5-F    Me                                     4-CF.sub.3                                                                          5-F      iPr        4-OCF.sub.3                                                                         5-F    iPr                                    4-CF.sub.3                                                                          5-F      Ph         4-OCF.sub.3                                                                         5-F    Ph                                     4-CF.sub.3                                                                          5-F      4-F--Ph    4-OCF.sub.3                                                                         5-F    4-F--Ph                                4-CF.sub.3                                                                          5-F      4-Cl--Ph   4-OCF.sub.3                                                                         5-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-Cl     Me         4-OCF.sub.3                                                                         5-Cl   Me                                     4-CF.sub.3                                                                          5-Cl     iPr        4-OCF.sub.3                                                                         5-Cl   iPr                                    4-CF.sub.3                                                                          5-Cl     Ph         4-OCF.sub.3                                                                         5-Cl   Ph                                     4-CF.sub.3                                                                          5-Cl     4-F--Ph    4-OCF.sub.3                                                                         5-Cl   4-F--Ph                                4-CF.sub.3                                                                          5-Cl     4-Cl--Ph   4-OCF.sub.3                                                                         5-Cl   4-Cl--Ph                               4-CF.sub.3                                                                          5-CF.sub.3                                                                             Me         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Me                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             iPr        4-OCF.sub.3                                                                         5-CF.sub.3                                                                           iPr                                    4-CF.sub.3                                                                          5-CF.sub.3                                                                             Ph         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Ph                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-F--Ph    4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-F--Ph                                4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-Cl--Ph   4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-Cl--Ph                               4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Me         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Me                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            iPr        4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          iPr                                    4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Ph         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Ph                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-F--Ph    4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-F--Ph                                4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-Cl--Ph   4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-Cl--Ph                               4-CF.sub.3                                                                          4-F      Me         4-OCF.sub.3                                                                         4-F    Me                                     4-CF.sub.3                                                                          4-F      iPr        4-OCF.sub.3                                                                         4-F    iPr                                    4-CF.sub.3                                                                          4-F      Ph         4-OCF.sub.3                                                                         4-F    Ph                                     4-CF.sub.3                                                                          4-F      4-F--Ph    4-OCF.sub.3                                                                         4-F    4-F--Ph                                4-CF.sub.3                                                                          4-F      4-Cl--Ph   4-OCF.sub.3                                                                         4-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-F      Me         4-OCF.sub.3                                                                         5-F    Me                                     4-CF.sub.3                                                                          5-F      iPr        4-OCF.sub.3                                                                         5-F    iPr                                    4-CF.sub.3                                                                          5-F      Ph         4-OCF.sub.3                                                                         5-F    Ph                                     4-CF.sub.3                                                                          5-F      4-F--Ph    4-OCF.sub.3                                                                         5-F    4-F--Ph                                4-CF.sub.3                                                                          5-F      4-Cl--Ph   4-OCF.sub.3                                                                         5-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-Cl     Me         4-OCF.sub.3                                                                         5-Cl   Me                                     4-CF.sub.3                                                                          5-Cl     iPr        4-OCF.sub.3                                                                         5-Cl   iPr                                    4-CF.sub.3                                                                          5-Cl     Ph         4-OCF.sub.3                                                                         5-Cl   Ph                                     4-CF.sub.3                                                                          5-Cl     4-F--Ph    4-OCF.sub.3                                                                         5-Cl   4-F--Ph                                4-CF.sub.3                                                                          5-Cl     4-Cl--Ph   4-OCF.sub.3                                                                         5-Cl   4-Cl--Ph                               4-CF.sub.3                                                                          5-CF.sub.3                                                                             Me         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Me                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             iPr        4-OCF.sub.3                                                                         5-CF.sub.3                                                                           iPr                                    4-CF.sub.3                                                                          5-CF.sub.3                                                                             Ph         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Ph                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-F--Ph    4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-F--Ph                                4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-Cl--Ph   4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-Cl--Ph                               4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Me         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Me                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            iPr        4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          iPr                                    4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Ph         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Ph                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-F--Ph    4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-F--Ph                                4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-Cl--Ph   4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-Cl--Ph                               4-CF.sub.3                                                                          4-F      Me         4-OCF.sub.3                                                                         4-F    Me                                     4-CF.sub.3                                                                          4-F      iPr        4-OCF.sub.3                                                                         4-F    iPr                                    4-CF.sub.3                                                                          4-F      Ph         4-OCF.sub.3                                                                         4-F    Ph                                     4-CF.sub.3                                                                          4-F      4-F--Ph    4-OCF.sub.3                                                                         4-F    4-F--Ph                                4-CF.sub.3                                                                          4-F      4-Cl--Ph   4-OCF.sub.3                                                                         4-F    4-Cl--Ph                               ______________________________________                                    

                  TABLE 34                                                        ______________________________________                                        R.sup.1                                                                             R.sup.2  R.sup.4    R.sup.1                                                                             R.sup.2                                                                              R.sup.4                                ______________________________________                                        4-CF.sub.3                                                                          5-F      Me         4-OCF.sub.3                                                                         5-F    Me                                     4-CF.sub.3                                                                          5-F      iPr        4-OCF.sub.3                                                                         5-F    iPr                                    4-CF.sub.3                                                                          5-F      Ph         4-OCF.sub.3                                                                         5-F    Ph                                     4-CF.sub.3                                                                          5-F      4-F--Ph    4-OCF.sub.3                                                                         5-F    4-F--Ph                                4-CF.sub.3                                                                          5-F      4-Cl--Ph   4-OCF.sub.3                                                                         5-f    4-Cl--Ph                               4-CF.sub.3                                                                          5-Cl     Me         4-OCF.sub.3                                                                         5-Cl   Me                                     4-CF.sub.3                                                                          5-Cl     iPr        4-OCF.sub.3                                                                         5-Cl   iPr                                    4-CF.sub.3                                                                          5-Cl     Ph         4-OCF.sub.3                                                                         5-Cl   Ph                                     4-CF.sub.3                                                                          5-Cl     4-F--Ph    4-OCF.sub.3                                                                         5-Cl   4-F--Ph                                4-CF.sub.3                                                                          5-Cl     4-Cl--Ph   4-OCF.sub.3                                                                         5-Cl   4-Cl--Ph                               4-CF.sub.3                                                                          5-CF.sub.3                                                                             Me         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Me                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             iPr        4-OCF.sub.3                                                                         5-CF.sub.3                                                                           iPr                                    4-CF.sub.3                                                                          5-CF.sub.3                                                                             Ph         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Ph                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-F--Ph    4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-F--Ph                                4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-Cl--Ph   4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-Cl--Ph                               4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Me         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Me                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            iPr        4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          iPr                                    4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Ph         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Ph                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-F--Ph    4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-F--Ph                                4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-Cl--Ph   4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-Cl--Ph                               4-CF.sub.3                                                                          4-F      Me         4-OCF.sub.3                                                                         4-F    Me                                     4-CF.sub.3                                                                          4-F      iPr        4-OCF.sub.3                                                                         4-F    iPr                                    4-CF.sub.3                                                                          4-F      Ph         4-OCF.sub.3                                                                         4-F    Ph                                     4-CF.sub.3                                                                          4-F      4-F--Ph    4-OCF.sub.3                                                                         4-F    4-F--Ph                                4-CF.sub.3                                                                          4-F      4-Cl--Ph   4-OCF.sub.3                                                                         4-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-F      Me         4-OCF.sub.3                                                                         5-F    Me                                     4-CF.sub.3                                                                          5-F      iPr        4-OCF.sub.3                                                                         5-F    iPr                                    4-CF.sub.3                                                                          5-F      Ph         4-OCF.sub.3                                                                         5-F    Ph                                     4-CF.sub.3                                                                          5-F      4-F--Ph    4-OCF.sub.3                                                                         5-F    4-F--Ph                                4-CF.sub.3                                                                          5-F      4-Cl--Ph   4-OCF.sub.3                                                                         5-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-Cl     Me         4-OCF.sub.3                                                                         5-Cl   Me                                     4-CF.sub.3                                                                          5-Cl     iPr        4-OCF.sub.3                                                                         5-Cl   iPr                                    4-CF.sub.3                                                                          5-Cl     Ph         4-OCF.sub.3                                                                         5-Cl   Ph                                     4-CF.sub.3                                                                          5-Cl     4-F--Ph    4-OCF.sub.3                                                                         5-Cl   4-F--Ph                                4-CF.sub.3                                                                          5-Cl     4-Cl--Ph   4-OCF.sub.3                                                                         5-Cl   4-Cl--Ph                               4-CF.sub.3                                                                          5-CF.sub.3                                                                             Me         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Me                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             iPr        4-OCF.sub.3                                                                         5-CF.sub.3                                                                           iPr                                    4-CF.sub.3                                                                          5-CF.sub.3                                                                             Ph         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Ph                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-F--Ph    4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-F--Ph                                4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-Cl--Ph   4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-Cl--Ph                               4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Me         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Me                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            iPr        4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          iPr                                    4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Ph         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Ph                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-F--Ph    4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-F--Ph                                4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-Cl--Ph   4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-Cl--Ph                               4-CF.sub.3                                                                          4-F      Me         4-OCF.sub.3                                                                         4-F    Me                                     4-CF.sub.3                                                                          4-F      iPr        4-OCF.sub.3                                                                         4-F    iPr                                    4-CF.sub.3                                                                          4-F      Ph         4-OCF.sub.3                                                                         4-F    Ph                                     4-CF.sub.3                                                                          4-F      4-F--Ph    4-OCF.sub.3                                                                         4-F    4-F--Ph                                4-CF.sub.3                                                                          4-F      4-Cl--Ph   4-OCF.sub.3                                                                         4-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-F      Me         4-OCF.sub.3                                                                         5-F    Me                                     4-CF.sub.3                                                                          5-F      iPr        4-OCF.sub.3                                                                         5-F    iPr                                    4-CF.sub.3                                                                          5-F      Ph         4-OCF.sub.3                                                                         5-F    Ph                                     4-CF.sub.3                                                                          5-F      4-F--Ph    4-OCF.sub.3                                                                         5-F    4-F--Ph                                4-CF.sub.3                                                                          5-F      4-Cl--Ph   4-OCF.sub.3                                                                         5-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-Cl     Me         4-OCF.sub.3                                                                         5-Cl   Me                                     4-CF.sub.3                                                                          5-Cl     iPr        4-OCF.sub.3                                                                         5-Cl   iPr                                    4-CF.sub.3                                                                          5-Cl     Ph         4-OCF.sub.3                                                                         5-Cl   Ph                                     4-CF.sub.3                                                                          5-Cl     4-F--Ph    4-OCF.sub.3                                                                         5-Cl   4-F--Ph                                4-CF.sub.3                                                                          5-Cl     4-Cl--Ph   4-OCF.sub.3                                                                         5-Cl   4-Cl--Ph                               4-CF.sub.3                                                                          5-CF.sub.3                                                                             Me         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Me                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             iPr        4-OCF.sub.3                                                                         5-CF.sub.3                                                                           iPr                                    4-CF.sub.3                                                                          5-CF.sub.3                                                                             Ph         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Ph                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-F--Ph    4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-F--Ph                                4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-Cl--Ph   4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-Cl--Ph                               4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Me         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Me                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            iPr        4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          iPr                                    4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Ph         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Ph                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-F--Ph    4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-F--Ph                                4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-Cl--Ph   4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-Cl--Ph                               4-CF.sub.3                                                                          4-F      Me         4-OCF.sub.3                                                                         4-F    Me                                     4-CF.sub.3                                                                          4-F      iPr        4-OCF.sub.3                                                                         4-F    iPr                                    4-CF.sub.3                                                                          4-F      Ph         4-OCF.sub.3                                                                         4-F    Ph                                     4-CF.sub.3                                                                          4-F      4-F--Ph    4-OCF.sub.3                                                                         4-F    4-F--Ph                                4-CF.sub.3                                                                          4-F      4-Cl--Ph   4-OCF.sub.3                                                                         4-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-F      Me         4-OCF.sub.3                                                                         5-F    Me                                     4-CF.sub.3                                                                          5-F      iPr        4-OCF.sub.3                                                                         5-F    iPr                                    4-CF.sub.3                                                                          5-F      Ph         4-OCF.sub.3                                                                         5-F    Ph                                     4-CF.sub.3                                                                          5-F      4-F--Ph    4-OCF.sub.3                                                                         5-F    4-F--Ph                                4-CF.sub.3                                                                          5-F      4-Cl--Ph   4-OCF.sub.3                                                                         5-F    4-Cl--Ph                               4-CF.sub.3                                                                          5-Cl     Me         4-OCF.sub.3                                                                         5-Cl   Me                                     4-CF.sub.3                                                                          5-Cl     iPr        4-OCF.sub.3                                                                         5-Cl   iPr                                    4-CF.sub.3                                                                          5-Cl     Ph         4-OCF.sub.3                                                                         5-Cl   Ph                                     4-CF.sub.3                                                                          5-Cl     4-F--Ph    4-OCF.sub.3                                                                         5-Cl   4-F--Ph                                4-CF.sub.3                                                                          5-Cl     4-Cl--Ph   4-OCF.sub.3                                                                         5-Cl   4-Cl--Ph                               4-CF.sub.3                                                                          5-CF.sub.3                                                                             Me         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Me                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             iPr        4-OCF.sub.3                                                                         5-CF.sub.3                                                                           iPr                                    4-CF.sub.3                                                                          5-CF.sub.3                                                                             Ph         4-OCF.sub.3                                                                         5-CF.sub.3                                                                           Ph                                     4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-F--Ph    4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-F--Ph                                4-CF.sub.3                                                                          5-CF.sub.3                                                                             4-Cl--Ph   4-OCF.sub.3                                                                         5-CF.sub.3                                                                           4-Cl--Ph                               4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Me         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Me                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            iPr        4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          iPr                                    4-CF.sub.3                                                                          5-OCF.sub.3                                                                            Ph         4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          Ph                                     4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-F--Ph    4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-F--Ph                                4-CF.sub.3                                                                          5-OCF.sub.3                                                                            4-Cl--Ph   4-OCF.sub.3                                                                         5-OCF.sub.3                                                                          4-Cl--Ph                               4-CF.sub.3                                                                          4-F      Me         4-OCF.sub.3                                                                         4-F    Me                                     4-CF.sub.3                                                                          4-F      iPr        4-OCF.sub.3                                                                         4-F    iPr                                    4-CF.sub.3                                                                          4-F      Ph         4-OCF.sub.3                                                                         4-F    Ph                                     4-CF.sub.3                                                                          4-F      4-F--Ph    4-OCF.sub.3                                                                         4-F    4-F--Ph                                4-CF.sub.3                                                                          4-F      4-Cl--Ph   4-OCF.sub.3                                                                         4-F    4-Cl--Ph                               ______________________________________                                    

                                      TABLE 35                                    __________________________________________________________________________    R.sup.1                                                                             R.sup.2                                                                            R.sup.3                                                                             R.sup.5                                                                           R.sup.1                                                                             R.sup.2                                                                            R.sup.3                                                                             R.sup.5                                 __________________________________________________________________________    4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         H   4-OCF.sub.3                                                                         4-Cl 4-Cl--Ph                                                                            H                                       4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl 4-Cl--Ph                                                                            H   4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl 4-Cl--Ph                                                                            H   4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl 4-Cl--Ph                                                                            H   4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl 4-Cl--Ph                                                                            H   4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         4-Cl--Ph                                                                            H   4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         4-Cl--Ph                                                                            H   4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         4-Cl--Ph                                                                            H   4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         4-Cl--Ph                                                                            H   4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         H   4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-Cl 4-Cl--Ph                                                                            H                                                            4-OCF.sub.3                                                                         4-Cl 4-Cl--Ph                                                                            H                                                            4-OCF.sub.3                                                                         4-Cl 4-Cl--Ph                                                                            H                                                            __________________________________________________________________________

                                      TABLE 36                                    __________________________________________________________________________    R.sup.1                                                                             R.sup.2                                                                            R.sup.3                                                                             R.sup.5                                                                           R.sup.1                                                                             R.sup.2                                                                            R.sup.3                                                                             R.sup.5                                 __________________________________________________________________________    4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         H   4-OCF.sub.3                                                                         4-CF.sub.3                                                                         4-F--Ph                                                                             H                                       4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H   4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl 4-F--Ph                                                                             H   4-CF.sub.3                                                                          4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl 4-F--Ph                                                                             H   4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl 4-F--Ph                                                                             H   4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-Cl 4-F--Ph                                                                             H   4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         4-F--Ph                                                                             H   4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         4-F--Ph                                                                             H   4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         4-F--Ph                                                                             H   4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-CF.sub.3                                                                          4-CF.sub.3                                                                         4-F--Ph                                                                             H   4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         H   4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         Me                                      4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-Cl CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         CO.sub.2 Me                                                                         H                                                            4-OCF.sub.3                                                                         4-Cl 4-F--Ph                                                                             H                                                            4-OCF.sub.3                                                                         4-Cl 4-F--Ph                                                                             H                                                            4-OCF.sub.3                                                                         4-Cl 4-F--Ph                                                                             H                                                            4-OCF.sub.3                                                                         4-Cl 4-F--Ph                                                                             H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         4-F--Ph                                                                             H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         4-F--Ph                                                                             H                                                            4-OCF.sub.3                                                                         4-CF.sub.3                                                                         4-F--Ph                                                                             H                                                            __________________________________________________________________________

Formulation and Use

The compounds of this invention will generally be used in formulationwith an agriculturally suitable carrier comprising a liquid or soliddiluent or an organic solvent. Useful formulations of the compounds ofFormula I can be prepared in conventional ways. They include dusts,granules, baits, pellets, solutions, suspensions, emulsions, wettablepowders, emulsifiable concentrates, dry flowables and the like. Many ofthese can be applied directly. Sprayable formualtions can be extended insuitable media and used at spray volumes of from about one to severalhundred liters per hectare. High strength compositions are primarilyused as intermediates for further formulation. The formulations,broadly, contain from less than about 1% to 99% by weight of activeingredient(s) and at least one of a) about 0.1% to 20% surfactant(s) andb) about 5% to 99% solid or liquid diluent(s). More specifically, theywill contain effective amounts of these ingredients in the followingapproximate proportions:

    ______________________________________                                                    Percent by Weight                                                             Active                                                                        Ingredient                                                                            Diluent(s)                                                                              Surfactant(s)                                   ______________________________________                                        Wettable Powders                                                                            25-90      0-74     1-10                                        Oil Suspensions,                                                                             5-50     40-95     0-15                                        Emulsions, Solutions                                                          (including Emulsifiable                                                       Concentrates)                                                                 Dusts          1-25     70-99     0-5                                         Granules, Baits                                                                             0.01-95    5-99     0-15                                        and Pellets                                                                   High Strength 90-99      0-10     0-2                                         Compositions                                                                  ______________________________________                                    

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook ofInsecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books,Caldwell, N.J. The more absorptive diluents are preferred for wettablepowders and the denser ones for dusts. Typical liquid diluents andsolvents are described in Marsden, "Solvents Guide," 2nd Ed.,Interscience, New York, 1950. Solubility under 0.1% is preferred forsuspension concentrates; solution concentrates are preferably stableagainst phase separation at 0° C. "McCutcheon's Detergents andEmulsifiers Annual", Allured Publ. Corp., Ridgewood, N.J., as well asSisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publ.Co., Inc., New York, 1964, list surfactants and recommended uses. Allformulations can contain minor amounts of additives to reduce foam,caking, corrosion, microbiological growth, etc. Preferably, ingredientsshould be approved by the U.S. Environmental Protection Agency for theuse intended.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet milling (see, for example, U.S.Pat. No. 3,060,084). Granules and pellets can be made by spraying theactive material upon preformed granular carriers or by agglomerationtechniques. See J. E. Browning, "Agglomeration", Chemical Engineering,Dec. 4, 1967, pages 147 and following, and "Perry's Chemical Engineer'sHandbook", 4th Ed., McGraw-Hill, New York, 1963, pages 8 to 59 andfollowing.

EXAMPLE A

    ______________________________________                                        Emulsifiable Concentrate                                                      ______________________________________                                        7-chloro-2,3,3a,4-tetrahydro-3a-(1-methylethyl)-N-                                                        20%                                               [4-(trifluoromethyl)phenyl][1]benzopyrano[4,3-c]-                             pyrazole-2-carboximidoyl chloride                                             blend of oil soluble sulfonates                                                                           10%                                               and polyoxyethylene ethers                                                    isophorone                  70%                                               ______________________________________                                    

The ingredients are combined and stirred with gentle warming to speedsolution. A fine screen filter is included in packaging operation toinsure the absence of any extraneous undissolved material in theproduct.

EXAMPLE B

    ______________________________________                                        Wettable Powder                                                               ______________________________________                                        N-(4-chlorophenyl)-4,5-dihydro-α-(methylthio)-4-                                                     30%                                              phenyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazole-                             1-methanimine                                                                 sodium alkylnaphthalenesulfonate                                                                           2%                                               sodium ligninsulfonate       2%                                               synthetic amorphous silica   3%                                               kaolinite                    63%                                              ______________________________________                                    

The active ingredient is mixed with the inert materials in a blender.After grinding in a hammermill, the material is re-blended and siftedthrough a 50 mesh screen.

EXAMPLE C

    ______________________________________                                        Dust                                                                          ______________________________________                                        Wettable powder of Example B                                                                        10%                                                     pyrophyllite (powder) 90%                                                     ______________________________________                                    

The wettable powder and the pyrophyllite diluent are thoroughly blendedand then packaged. The product is suitable for use as a dust.

EXAMPLE D

    ______________________________________                                        Granule                                                                       ______________________________________                                        1-(4-chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-                                                        10%                                               N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-                                  carboximidoyl chloride                                                        attapulgite granules (low volative matter,                                                                90%                                               0.71/0.30 mm; U.S.S. No. 25-50 sieves)                                        ______________________________________                                    

The active ingredient is dissolved in a volatile solvent such as acetoneand sprayed upon dedusted and pre-warmed attapulgite granules in adouble cone blender. The acetone is then driven off by heating. Thegranules are then allowed to cool and are packaged.

EXAMPLE E

    ______________________________________                                        Granule                                                                       ______________________________________                                        Wettable powder of Example B                                                                        15%                                                     gypsum                69%                                                     potassium sulfate     16%                                                     ______________________________________                                    

The ingredients are blended in a rotating mixer and water sprayed on toaccomplish granulation. When most of the material has reached thedesired range of 0.1 to 0.42 mm (U.S. Ser. No. 18 to 40 sieves), thegranules are removed, dried, and screened. Oversize material is crushedto produce additional material in the desired range. These granulescontain 4.5% active ingredient.

EXAMPLE F

    ______________________________________                                        Solution                                                                      ______________________________________                                        7-chloro-2,3,3a,4-tetrahydro-3a-(1-methylethyl)-N-                                                        25%                                               [4-(trifluoromethyl)phenyl][1]benzopyrano[4,3-c]-                             pyrazole-2-carboximidoyl chloride                                             N-methyl-pyrrolidone        75%                                               ______________________________________                                    

The ingredients are combined and stirred to produce a solution suitablefor direct, low volume application.

EXAMPLE G

    ______________________________________                                        Aqueous Suspension                                                            ______________________________________                                        N-(4-chlorophenyl)-4,5-dihydro-α-(methylthio)-4-                                                    40%                                               phenyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazole-                             1-methanimine                                                                 polyacrylic acid thickener  0.3%                                              dodecyclophenol polyethylene glycol                                                                       0.5%                                              ether                                                                         disodium phosphate          1.0%                                              monosodium phosphate        0.5%                                              polyvinyl alcohol           1.0%                                              water                       56.7%                                             ______________________________________                                    

The ingredients are blended and ground together in a sand mill toproduce particles substantially all under 5 microns in size.

EXAMPLE H

    ______________________________________                                        Oil Suspension                                                                ______________________________________                                        1-(4-chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-                                                        35.0%                                             N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-                                  carboximidoyl chloride                                                        blend of polyalcohol carboxylic                                                                           6.0%                                              esters and oil soluble petroleum sulfonates                                   xylene range solvent        59.0%                                             ______________________________________                                    

The ingredients are combined and ground together in a sand mill toproduce particles substantially all below 5 microns. The product can beused directly, extended with oils, or emulsified in water.

EXAMPLE I

    ______________________________________                                        Bait Granules                                                                 ______________________________________                                        1-(4-chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-                                                        3.0%                                              N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-                                  carboximidoyl chloride                                                        blend of polyethoxylated nonylphenols                                                                     9.0%                                              and sodium dodecylbenzene sulfonates                                          ground up corn cobs         88.0%                                             ______________________________________                                    

The active ingredient and surfactant blend are dissolved in a suitablesolvent such as acetone and sprayed onto the ground corn cobs. Thegranules are then dried and packaged.

Compounds of Formula I can also be mixed with one or more otherinsecticides, fungicides, nematocides, bactericides, acaricides, orother biologically active compounds to form a multi-component pesticidegiving an even broader spectrum of effective agricultural protection.Examples of other agricultural protectants with which compounds of thisinvention can be formulated are:

Insecticides:

3-hydroxy-N-methylcrotonamide(dimethylphosphate)ester (monocrotophos)

methylcarbamic acid, ester with 2,3-dihydro-2,2-dimethyl-7-benzofuranol(carbofuran)

O-[2,4,5-trichloro-α-(chloromethyl)benzyl]phosphoric acid,O',O'-dimethyl ester (tetrachlorvinphos)

2-mercaptosuccinic acid, diethyl ester, S-ester with thionophosphoricacid, dimethyl ester (malathion)

phosphorothioic acid, O,O-dimethyl, O-p-nitrophenyl ester (methylparathion)

methylcarbamic acid, ester with α-naphthol (carbaryl)

methyl O-(methylcarbamoyl)thiolacetohydroxamate (methomyl)

N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine (chlordimeform)

O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidylphosphorothioate(diazinon)

octachlorocamphene (toxaphene)

O-ethyl-O-p-nitrophenyl phenylphosphonothioate (EPN)

(S)-α-cyano-m-phenoxybenzyl(1R,3R)-3-(2,2-dibromovinyl)

-2,2-dimethylcyclopropanecarboxylate (deltamethrin)

Methyl-N',N'-dimethyl-N-[(methylcarbamoyl)oxy]-1-thioox amimidate(oxamyl)

cyano(3-phenoxyphenyl)-methyl-4-chloro-a-(1-methylethyl)benzeneacetate(fenvalerate)

(3-phenoxyphenyl)methyl(+)-cis,trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate (permethrin)

α-cyano-3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (cypermethrin)

O-ethyl-S-(p-chlorophenyl)ethylphosphonodithioate (profenofos)

phosphorothiolothionic acid,

O-ethyl-O-[4-(methylthio)-phenyl]-S-n-propyl ester (sulprofos).

Additional insecticides are listed hereafter by their common names:triflumuron, diflubenzuron, methoprene, buprofezin, thiodicarb,acephate, azinphosmethyl, chlorpyrifos, dimethoate, fonophos,isofenphos, methidathion, methamidiphos, monocrotphos, phosmet,phosphamidon, phosalone, pirimicarb, phorate, profenofos, terbufos,trichlorfon, methoxychlor, bifenthrin, biphenate, cyfluthrin,fenpropathrin, fluvalinate, flucythrinate, tralomethrin, metaldehyde androtenone.

Fungicides:

methyl 2-benzimidazolecarbamate (carbendazim)

tetramethylthiuram disulfide (thiuram)

n-dodecylguanidine acetate (dodine)

manganese ethylenebisdithiocarbamate (maneb)

1,4-dichloro-2,5-dimethoxybenzene (chloroneb)

methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate (benomyl)

1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole(propiconazole)

2-cyano-N-ethylcarbamoyl-2-methoxyiminoacetamide (cymoxanil)

1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone(triadimefon)

N-(trichloromethylthio)tetrahydrophthalimide (captan)

N-(trichloromethylthio)phthalimide (folpet)

1-[[[bis(4-fluorophenyl)][methyl]silyl]methyl]-1H-1,2,4-triazole.

Nematocides:

S-methyl 1-(dimethylcarbamoyl)-N-(methylcarbamoyloxy)thioformimidate

S-methyl 1-carbamoyl-N-(methylcarbamoyloxy)thioformimidate

N-isopropylphosphoramidic acid, O-ethyl

O'-[4-(methylthio)-m-tolyl]diester (fenamiphos)

Bactericides:

tribasic copper sulfate

streptomycin sulfate

Acaricides:

senecionic acid, ester with 2-sec-butyl-4,6-dinitrophenol (binapacryl)

6-methyl-1,3-cithiolo[4,5-β]quinoxalin-2-one (oxythioquinox)

ethyl 4,4'-dichlorobenzilate (chlorobenzilate)

1,1-bis(p-chlorophenyl)-2,2,2-trichloroethanol (dicofol)

bis(pentachloro-2,4-cyclopentadien-1-yl) (dienochlor)

tricyclohexyltin hydroxide (cyhexatin)

trans-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxothiazolidine-3-carboxamide(hexythiazox)

amitraz

propargite

fenbutatin-oxide

Biological

Bacillus thuringiensis

Avermectin B.

Utility

The compounds of this invention exhibit activity against a wide spectrumof foliar and soil inhabiting arthropods which are pests of growing andstored agronomic crops, forestry, greenhouse crops, ornamentals, nurserycrops, stored food and fiber products, livestock, household, and publicand animal health. Those skilled in the art will recognize that not allcompounds are equally effective against all pests but the compounds ofthis invention display activity against economically importantagronomic, forestry, greenhouse, ornamental food and fiber product,stored product, domestic structure, and nursery pests, such as:

larvae of the order Lepidotera including fall and beet armyworm andother Spodoptera spp., tobacco budworm, corn earworm and other Heliothisspp., European corn borer, navel orangeworm, stalk/stem borers and otherpyralids, cabbage and soybean loopers and other loopers, codling moth,grape berry moth and other tortricids, black cutworm, spotted cutworm,other cutworms and other noctuids, diamondback moth, green cloverworm,velvetbean caterpillar, green cloverworm, pink bollworm, gypsy moth, andspruce budworm;

foliar feeding larvae and adults of the order Coleoptera includingColorado potato beetle, Mexican bean beetle, flea beetle, Japanesebeetles, and other leaf beetles, boll weevil, rice water weevil, granaryweevil, rice weevil and other weevil pests, and soil inhabiting insectssuch as Western corn rootworm and other Diabrotica spp., Japanesebeetle, European chafer and other coleopteran grubs, and wireworms;

adults and larvae of the orders Hemiptera and Homoptera includingtarnished plant bug and other plant bugs (miridae), aster leafhopper andother leafhoppers (cicadellidae), rice planthopper, brown planthopper,and other planthoppers (fulgoroidea), psylids, whiteflies (aleurodidae),aphids (aphidae), scales (coccidae and diaspididae), lace bugs(tingidae), stink bugs (pentatomidae), cinch bugs and other seed bugs(lygaeidae), cicadas (cicadidae), spittlebugs (cercopids), squash bugs(coreidae), red bugs and cotton stainers (pyrrhocoridae);

adults and larvae of the order acari (mites) including European redmite, two spotted spider mite, rust mites, McDaniel mite, and foliarfeeding mites;

adults and immatures of the order Orthoptera including grasshoppers;

adults and immatures of the order Diptera including leafminers, midges,fruit flies (tephritidae), and soil maggots;

adults and immatures of the order Thysanoptera including onion thripsand other foliar feeding thrips.

The compounds are also active against economically important livestock,household, public and animal health pests such as:

insect pests of the order Hymenoptera including carpenter ants, bees,hornets, and wasps;

insect pests of the order Diptera including house flies, stable flies,face flies, horn flies, blow flies, and other muscoid fly pests, horseflies, deer flies and other Brachycera, mosquitoes, black flies, bitingmidges, sand flies, sciarids, and other Nematocera;

insect pests of the order Orthoptera including cockroaches and crickets;

insect pests of the order Isoptera including the Eastern subterraneantermite and other termites;

insect pests of the order Mallophaga and Anoplura including the headlouse, body louse, chicken head louse and other sucking and chewingparasitic lice that attack man and animals;

insect pests of the order Siphonoptera including the cat flea, dog fleaand other fleas.

The specific species for which control is exemplified are: fallarmyworm, Spodoptera fruigiperda; tobacco budworm, Heliothis virescens;boll weevil, Anthonomus grandis; aster leafhopper, Macrostelesfascifrons; black bean aphid, (Aphis Fabae); southern corn rootworm,Diabrotica undecimpunctata. The pest control protection afforded by thecompounds of the present invention is not limited, however, to thesespecies. The compounds of this invention may also be utilized asrodenticides.

Application

Arthropod pests are controlled and protection of agronomic crops, animaland human health is achieved by applying one or more of the Formula Icompounds of this invention, in an effective amount, to the environmentof the pests including the agronomic and/or nonagronomic locus ofinfestation, to the area to be protected, or directly on the pests to becontrolled. Because of the diversity of habitat and behavior of thesearthropod pest species, many different methods of application areemployed. A preferred method of application is by spraying withequipment that distributes the compound in the environment of the pests,on the foliage, animal, person, or premise, in the soil or animal, tothe plant part that is infested or needs to be protected. Alternatively,granular formulations of these toxicant compounds can be applied to orincorporated into the soil. Other methods of application can also beemployed including direct and residual sprays, aerial sprays, baits,eartags, boluses, foggers, aerosols, and many others. The compounds canbe incorporated into baits that are consumed by the arthropods or indevices such as traps and the like which entice them to ingest orotherwise contact the compounds.

The compounds of this invention can be applied in their pure state, butmost often application will be of a formulation comprising one or morecompounds with suitable carriers, diluents, and surfactants and possiblyin combination with a food depending on the contemplated end use. Apreferred method of application involves spraying a water dispersion orrefined oil solution of the compounds. Combinations with spray oils,spray oil concentrations, and synergists such as piperonyl butoxideoften enhance the efficacy of the compounds of Formula I.

The rate of application of the Formula I compounds required foreffective control will depend on such factors as the species ofarthropod to be controlled, the pest's life cycle, life stage, its size,location, time of year, host crop or animal, feeding behavior, matingbehavior, ambient moisture, temperature, etc. In general, applicationrates of 0.01 to 2 kg of active ingredient per hectare are sufficient toprovide large-scale effective control of pests in agronomic ecosystemsunder normal circumstances, but as little as 0.001 kg/hectare or as muchas 8 kg hectare may be required. For nonagronomic applications,effective use rates will range from about 1.0 to 50 mg/square meter butas much as 150 mg/square meter may be required.

The following Examples demonstrate the control efficacy of compounds ofFormula I on specific pests; see Index Table A for compounddescriptions.

    __________________________________________________________________________    INDEX TABLE A                                                                  ##STR34##                                                                    CMPD                                                                              Q X.sup.1                                                                            V  Y.sup.1                                                                         R.sup.1                                                                           R.sup.2                                                                           R.sup.3                                                                            R.sup.4                                                                          R.sup.5                                                                         mp(°C.)                              __________________________________________________________________________    1   4 Cl   -- --                                                                              4-CF.sub.3                                                                        4-Cl                                                                              CO.sub.2 Me                                                                        -- H 115-118                                     2   5 Cl   -- --                                                                              4-CF.sub.3                                                                        4-Cl                                                                              4-FPh                                                                              -- H 154-156                                     3   1 Cl   O  --                                                                              4-CF.sub.3                                                                        7-Cl                                                                              iPr  -- --                                                                              148-149                                     4   1 Cl   O  --                                                                              4-CF.sub.3                                                                        7-CF.sub.3                                                                        CO.sub.2 Me                                                                        -- --                                                                              150-152                                     5   1 Cl   O  --                                                                              4-CF.sub.3                                                                        6-F 4-FPh                                                                              -- --                                                                              184-186                                     6   4 SMe  -- --                                                                              4-Cl                                                                              4-CF.sub.3                                                                        Ph   -- H oil                                         7   1 SMe  O  --                                                                              4-CF.sub.3                                                                        7-CF.sub.3                                                                        H    -- --                                                                              oil                                         8   3 SMe  CH.sub.2                                                                         H 4-CF.sub.3                                                                        5-F --   Ph H 135-137                                     9   3 SCH.sub.2 Ph                                                                       CH.sub.2                                                                         H 4-CF.sub.3                                                                        5-F --   Ph H oil                                         10  1 OCO.sub.2 Me                                                                       O  --                                                                              4-CF.sub.3                                                                        7-CF.sub.3                                                                        CO.sub.2 Me                                                                        -- --                                                                              112-114                                     __________________________________________________________________________     ##STR35##                                                                    CMPD                                                                              Q   X.sup.2 R.sup.2                                                                           R.sup.3                                                                            R.sup.4                                                                            R.sup.5                                                                         mp(°C.)                                __________________________________________________________________________    11  5   OH      4-Cl                                                                              4-FPh                                                                              --   H 188-191                                       12  5   OCONHMe 4-Cl                                                                              4-FPh                                                                              --   H 75-77                                         __________________________________________________________________________     ##STR36##                                                                    CMPD Q X.sup.1                                                                            R.sup.1                                                                          R.sup.2                                                                             R.sup.3                                                                          R.sup.4                                                                           R.sup.5                                                                          (mp°C.)                                 __________________________________________________________________________    13   4 SMe  4-Cl                                                                             4-CF.sub.3                                                                          Ph --  H  194-195                                        __________________________________________________________________________     ##STR37##                                                                    CMPD                                                                              Q R.sup.3                                                                            V  A  X Y  R.sup.1                                                                           R.sup.2                                                                          R    mp(°C.)                              __________________________________________________________________________    14  6 CO.sub.2 Me                                                                        O  -- O H  4-CF.sub.3                                                                        H  H    211-212                                     15  6 CO.sub.2 Me                                                                        O  -- O H  4-CF.sub.3                                                                        H  CONHMe                                                                             208-209                                     16  6 4-FPh                                                                              O  -- O H  4-CF.sub.3                                                                        H  H    155-158                                     17  9 4-ClPh                                                                             -- -- O H  4-CF.sub.3                                                                        4-Cl                                                                             H    242-243                                     18  6 Ph   O  -- O H  4-CF.sub.3                                                                        H  H    197-203                                     19  8 4-FPh                                                                              -- CH.sub.2                                                                         O H  4-CF.sub.3                                                                        5-F                                                                              H    167-170                                     20  10                                                                              4-FPh                                                                              -- -- O H  4-CF.sub.3                                                                        Cl H    50-55                                       __________________________________________________________________________

EXAMPLE J

Fall Armyworm

Test units, each consisting of an 8-ounce (230 mL) plastic cupcontaining a layer of wheat germ diet, approximately 0.5 cm thick, wereprepared. Ten third-instar larvae of fall armyworm (Spodopterafrugiperda) were placed into each cup. Solutions of each of the testcompounds (acetone/distilled water 75/25 solvent) were sprayed onto thecups, a single solution per set of three cups. Spraying was accomplishedby passing the cups, on a conveyer belt, directly beneath a flat fanhydraulic nozzle which discharged the spray at a rate of 0.5 pounds ofactive ingredient per acre (about 0.55 kg/ha) at 30 p.s.i (207 kPa). Thecups were then covered and held at 27° C. and 50% relative humidity for72 hours, after which time readings were taken. Of the compounds tested,the following resulted in greater than or equal to 80% mortality: 1, 2,6, 9, 10, 11, 12, 13, 14, 16 and 17.

EXAMPLE K

Tobacco Budworm

The test procedure of Example J was repeated for efficacy againstthird-instar larvae of the tobacco budworm (Heliothis virescens) exceptthat mortality was assessed at 48 hours. Of the compounds tested, thefollowing resulted in greater than or equal to 80% mortality: 2, 9, 10,11, 14, 15 and 16.

EXAMPLE L

Southern Corn Rootworm

Test units, each consisting of an 8-ounce (230 mL) plastic cupcontaining 1 sprouted corn seed, were prepared. Sets of three test unitswere sprayed as described in Example J with individual solutions of thetest compounds. After the spray on the cups had dried, five third-instarlarvae of the southern corn rootworm (Diabrotica undecimpunctata howardi) were placed into each cup. A moistened dental wick was inserted intoeach cup to prevent drying and the cups were then covered. The cups werethen held at 27° C. and 50% relative humidity for 48 hours, after whichtime mortality readings were taken. Of the compounds tested, thefollowing resulted in greater than or equal to 80% mortality: 2, 8, 10,11, 13, 14, 15, 17 and 18.

EXAMPLE M

Aster Leafhopper

Test units were prepared from a series of 12-ounce (345 mL) cups, eachcontaining oat (Avena sativa) seedlings in a 2.54 cm layer of sterilizedsoil. The test units were sprayed as described in Example J withindividual solutions of the below-listed compounds. After the oats haddried from the spraying, between 10 and 15 adult aster leafhoppers(Mascrosteles fascifrons) were aspirated into each of the covered cups.The cups were held at 27° C. and 50% relative humidity for 48 hours,after which time mortality readings were taken. Of the compounds tested,the following resulted in greater than or equal to 80% mortality: 1, 10,14, 15 and 16.

EXAMPLE N

Black Bean Aphid

Test units were prepared, each consisting of a single nasturtium(Tropaeolum sp.) leaf infested with 5 to 10 black bean aphids (Aphisfabae). Each leaf was cut and individually held in a 1-dram glass vialfilled with a 10% sugar solution prior to and after spraying. Duringspraying, the infested leaves were inverted to expose the aphids, andeach leaf was held in place by a clip. Three test units with leaves weresprayed with individual solutions of the below-listed compoundsfollowing the spray procedure of Example J. Sprayed leaves were returnedto the individual glass vials, covered with a clear plastic 1-ounce (29mL) cup and were held at 27° C. and 50% relative humidity for 48 hours,after which time mortality readings were taken. None of the compoundsthat were tested exhibited mortality of 80% or greater.

EXAMPLE 0

Boll Weevil

Five adult boll weevils (Anthonomus grandis) were placed into each of aseries of 9-ounce (260 mL) cups. The test procedure employed was thenotherwise the same as in Example J. Mortality readings were taken 48hours after treatment. Of the compounds tested, the following resultedin greater than or equal to 80% mortality: 3, 4, 6, 7, 8, 10, 13, 14,15, 16 and 18.

EXAMPLE P

Two-Spotted Spider Mite

Test units, each consisting of 2.54 cm² sections of kidney bean leaves,were infested with 20 to 30 adult two-spotted spider mites (Tetranychusurticae) and sprayed as described in Example J with individual solutionsof the below-listed compounds. Three test units were sprayed persolution. Sprayed leaf sections were then placed on a layer of moistenedcotton in a Petri dish and held at 27° C. and 50% relative humidity for48 hours, after which time mortality readings were taken. None of thecompounds that were tested exhibited mortality of 80% or greater.

What is claimed is:
 1. A compound of the formula ##STR38## wherein: Q isattached to the carbon terminus of W and is selected from the group##STR39## W is selected from the group ##STR40## wherein: V is O;X isselected from the group O and S; X¹ is selected from the group Cl, Br,OR⁶, SR⁶, and NR⁶ R⁷ ; X² is selected from the group R⁶, OH, OR⁶, CN,SO₂ R⁶, OC(O)NR⁷ R⁸, OC(O)OCH₃, NR⁷ R⁸, phenyl optionally substitutedwith R⁹ and SO₂ Ph optionally substituted with R⁹ ; Y is selected fromthe group H, C₁ -C₆ alkyl, benzyl, C₂ -C₆ alkoxyalkyl, CHO, C₂ -C₆alkylcarbonyl, C₂ -C₆ alkoxycarbonyl, C₂ -C₆ haloalkylcarbonyl, C₁ -C₆alkylthio, C₁ -C₆ haloalkylthio, phenylthio, R¹⁷ OC(O)N(R)¹⁸ S andSN(R¹⁹)R²⁰ ; R is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄haloalkyl, C₂ -C₄ alkylcarbonyl, C₂ -C₄ haloalkylcarbonyl, C₂ -C₄alkoxycarbonyl, C₂ -C₄ haloalkoxycarbonyl, C₂ -C₅ alkylcarbamoyl, C₃ -C₆cycloalkyl, C₃ -C₆ halocycloalkyl, C₄ -C₇ alkylcycloalkyl, C₄ -C₇haloalkylcycloalkyl, C₁ -C₄ alkylsulfonyl, C₁ -C₄ haloalkylsulfonyl andSO₂ Ph; R¹, R², R⁹, R¹⁰, R¹⁴ are each independently selected from thegroup H, halogen, CN, C₁ -C₃ haloalkyl, C₁ -C₃ haloalkoxy and OS(O)₂ C₁-C₃ haloalkyl; R³ is selected from the group H, C₁ -C₆ alkyl, C₂ -C₆alkenyl, CO₂ R¹³ and phenyl optionally substituted by (R¹⁴)_(p) ; R⁵ isselected from the group H and C₁ -C₄ alkyl; R⁶ is selected from thegroup C₁ -C₃ alkyl, benzyl optionally substituted with R⁹, C₂ -C₄alkenyl, C₂ -C₄ alkynyl, C₁ -C₃ haloalkyl, C₂ -C₄ haloalkenyl, C₂ -C₃alkoxycarbonyl, C₃ -C₆ cycloalkyl and C₂ -C₃ alkylcarbonyl; or R⁶ is C₁-C₃ alkyl substituted with a member selected from the group OCH₃, OCH₂CH₃, NO₂, CN, CO₂ CH₃, CO₂ CH₂ CH₃, SCH₃ and SCH₂ CH₃ ; R⁷ is selectedfrom the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkoxycarbonyl,phenyl optionally substituted with R¹⁰ and pyridyl optionallysubstituted with R¹⁰ ; or R⁶ and R⁷ are taken together as CH₂ CH₂ CH₂CH₂, CH₂ CH₂ CH₂ CH₂ CH₂, or CH₂ CH₂ OCH₂ CH₂ when X¹ is NR⁶ R⁷ ; R⁸ isselected from the group H and C₁ -C₄ alkyl; or R⁷ and R⁸ are takentogether as CH₂ CH₂ CH₂ CH₂, CH₂ CH₂ CH₂ CH₂ CH₂, or CH₂ CH₂ OCH₂ CH₂ ;R¹³ is selected from the group H and C₁ -C₃ alkyl; R¹⁷ is selected fromC₁ -C₆ alkyl; R¹⁸ is selected from C₁ -C₆ alkyl; R¹⁹ and R²⁰ areindependently C₁ -C₄ alkyl; or R¹⁹ and R²⁰ are taken together as CH₂ CH₂CH₂ CH₂ CH₂ or CH₂ CH₂ OCH₂ CH₂ ; m is 1 or 2; n is 1 or 2; and p is 1or 2; wherein when Q is Q-1, then W is W-2 or W-3.
 2. A compoundaccording to claim 1 wherein:X is O; X¹ is selected from the group Cl,SR⁶, N(CH₃)₂ and OR⁶ ; X² is selected from the group CN, OR⁶, OH andN(CH₃)₂ ; R is H; R¹, R², R¹⁴ are each independently selected from thegroup H, F, Cl, Br, CF₃, OCF₃, OCF₂ H, OCH₂ CF₃ and OSO₂ CF₃ ; R³ isselected from the group CO₂ CH₃, CH(CH₃)₂, CH₃ and phenyl optionallysubstituted with R¹⁴ ; R⁵ is selected from the group H and CH₃ ; R⁶ isC₁ -C₂ alkyl; Y is selected from the group H, C(O)CH₃, CH₃ and CO₂ CH₃ ;and m and n are
 1. 3. A compound according to claim 2 wherein Q is Q-1and W is W-2.
 4. A compound according to claim 2 wherein Q is Q-1 and Wis W-3.
 5. A compound according to claim 2 wherein Q is Q-6 and W isW-1.
 6. An arthropodicidal composition comprising a compound accordingto claim 1 and a carrier therefor.
 7. A method for controllingarthropods comprising contacting them or their environment with anarthropodicidally effective amount of a compound according to any one ofclaims 1 to 3, 4 and 5.